神经干细胞TSP50缺乏通过改变肠道微生物群加重小鼠结肠炎。

IF 9.2 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Xiaoli Li, Rong Jin, Zhaoxia Wang, Chunxue Niu, Zhenbo Song, Xiaoling Liu, Jian Huang, Huan Zhang, Xia Qian, Feng Gao, Shuyue Wang, Chunlei Yu, Luguo Sun, Yanxin Huang, Lihua Zheng, Guannan Wang, Ying Sun, Xiaoguang Yang, Yongli Bao, Jiawei Li
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引用次数: 0

摘要

炎症性肠病(IBD)是一种以胃肠道持续慢性炎症和周期性发作为特征的复杂疾病。尽管相关研究越来越多,但IBD的详细发病机制尚未阐明。近年来,宿主-微生物群在IBD发病机制中的相互作用受到了广泛关注。睾丸特异性蛋白酶50 (Testes-specific protease 50, TSP50)是IBD的潜在风险基因,但其是否能通过调节肠道菌群影响结肠炎易感性尚不清楚。在这里,我们发现神经干细胞(NSCs)中TSP50缺乏通过改变肠道微生物组加重了小鼠结肠炎。机制上,TSP50通过降解乙酰胆碱酯酶(AChE)维持神经递质乙酰胆碱(ACh)水平,从而维持肠黏膜和肠道微生态稳态,降低结肠炎易感性。这些发现为宿主与共生菌群之间的相互作用提供了新的视角,这可能有助于制定IBD的潜在治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TSP50 deficiency in neural stem cells aggravates colitis in mice by altering intestinal microbiome.

Inflammatory bowel disease (IBD) is a complex disease characterized by persistent chronic inflammation of the gastrointestinal tract and periodic episodes. Despite the increasing number of related studies, the detailed pathogenesis of IBD has not been elucidated. In recent years, host-microbiota interactions in the pathogenesis of IBD have received extensive attention. Testes-specific protease 50 (TSP50) is a potential risk gene for IBD, but whether it can affect the susceptibility of colitis by regulating the gut microbiome is still unclear. Here, we showed that TSP50 deficiency in neural stem cells (NSCs) aggravated colitis in mice by altering intestinal microbiome. Mechanistically, TSP50 maintained the level of neurotransmitter acetylcholine (ACh) by degrading acetylcholinesterase (AChE), thereby maintaining intestinal mucosa and intestinal microecological homeostasis and reducing the susceptibility to colitis. These findings provide a new perspective on the interaction between host and commensal microbiota, which may be beneficial for developing potential therapeutic strategies for IBD.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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