{"title":"高敏c反应蛋白与动脉硬化进展的关系：开滦研究。","authors":"Weizhe Li, Pei Liang, Xueliang Ma, Yanling Gao, Xiaoxin Bai, Shasha An, Xin Wang, Shuohua Chen, Shouling Wu","doi":"10.2147/JIR.S524495","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between high-sensitivity C-reactive protein (hs-CRP) and the progression of arteriosclerosis.</p><p><strong>Methods: </strong>Using a prospective cohort study design, 11,577 participants from the Kailuan Study cohort who underwent at least two brachial-ankle pulse wave velocity (baPWV) examinations and met the inclusion criteria were included as the study subjects. Based on baseline hs-CRP levels, they were divided into three groups: hs-CRP <1 mg/L group, 1 mg/L≤hs-CRP≤3 mg/L group, and hs-CRP >3 mg/L group. Poisson regression analysis was employed for longitudinal comparison to assess the impact of different hs-CRP levels on baPWV≥1,400 cm/s.</p><p><strong>Results: </strong>(1) After a mean follow-up of 5.12 ± 2.84 years, the detection rates of baPWV≥1,400 cm/s at the end of follow-up were 28.54%, 33.36%, and 36.25% in the hs-CRP<1 mg/L (n=5,998), 1 mg/L≤ hs-CRP≤3 mg/L (n=4,101), and hs-CRP>3 mg/L (n=1,578) groups, respectively (<i>P</i><0.001). (2) Multivariable-adjusted Poisson regression analysis for baPWV≥1,400 cm/s showed that, after adjusting for confounding factors, compared to the hs-CRP<1 mg/L group, the 1 mg/L≤hs-CRP≤3 mg/L group had a 2.4% higher risk of arterial stiffness (RR: 1.024; 95% CI: 1.002 to 1.047; <i>P</i><0.05) and hs-CRP>3 mg/L group had a 6.3% higher risk (RR: 1.063; 95% CI: 1.031 to 1.095; <i>P</i><0.001). Sensitivity analysis validated the robustness of the results.</p><p><strong>Conclusion: </strong>Elevated hs-CRP is an independent risk factor for arteriosclerosis progression.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"7047-7054"},"PeriodicalIF":4.2000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132636/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Association Between High-Sensitivity C-Reactive Protein and the Progression of Arteriosclerosis: The Kailuan Study.\",\"authors\":\"Weizhe Li, Pei Liang, Xueliang Ma, Yanling Gao, Xiaoxin Bai, Shasha An, Xin Wang, Shuohua Chen, Shouling Wu\",\"doi\":\"10.2147/JIR.S524495\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the association between high-sensitivity C-reactive protein (hs-CRP) and the progression of arteriosclerosis.</p><p><strong>Methods: </strong>Using a prospective cohort study design, 11,577 participants from the Kailuan Study cohort who underwent at least two brachial-ankle pulse wave velocity (baPWV) examinations and met the inclusion criteria were included as the study subjects. Based on baseline hs-CRP levels, they were divided into three groups: hs-CRP <1 mg/L group, 1 mg/L≤hs-CRP≤3 mg/L group, and hs-CRP >3 mg/L group. Poisson regression analysis was employed for longitudinal comparison to assess the impact of different hs-CRP levels on baPWV≥1,400 cm/s.</p><p><strong>Results: </strong>(1) After a mean follow-up of 5.12 ± 2.84 years, the detection rates of baPWV≥1,400 cm/s at the end of follow-up were 28.54%, 33.36%, and 36.25% in the hs-CRP<1 mg/L (n=5,998), 1 mg/L≤ hs-CRP≤3 mg/L (n=4,101), and hs-CRP>3 mg/L (n=1,578) groups, respectively (<i>P</i><0.001). (2) Multivariable-adjusted Poisson regression analysis for baPWV≥1,400 cm/s showed that, after adjusting for confounding factors, compared to the hs-CRP<1 mg/L group, the 1 mg/L≤hs-CRP≤3 mg/L group had a 2.4% higher risk of arterial stiffness (RR: 1.024; 95% CI: 1.002 to 1.047; <i>P</i><0.05) and hs-CRP>3 mg/L group had a 6.3% higher risk (RR: 1.063; 95% CI: 1.031 to 1.095; <i>P</i><0.001). Sensitivity analysis validated the robustness of the results.</p><p><strong>Conclusion: </strong>Elevated hs-CRP is an independent risk factor for arteriosclerosis progression.</p>\",\"PeriodicalId\":16107,\"journal\":{\"name\":\"Journal of Inflammation Research\",\"volume\":\"18 \",\"pages\":\"7047-7054\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132636/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Inflammation Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/JIR.S524495\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inflammation Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JIR.S524495","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
The Association Between High-Sensitivity C-Reactive Protein and the Progression of Arteriosclerosis: The Kailuan Study.
Objective: To explore the association between high-sensitivity C-reactive protein (hs-CRP) and the progression of arteriosclerosis.
Methods: Using a prospective cohort study design, 11,577 participants from the Kailuan Study cohort who underwent at least two brachial-ankle pulse wave velocity (baPWV) examinations and met the inclusion criteria were included as the study subjects. Based on baseline hs-CRP levels, they were divided into three groups: hs-CRP <1 mg/L group, 1 mg/L≤hs-CRP≤3 mg/L group, and hs-CRP >3 mg/L group. Poisson regression analysis was employed for longitudinal comparison to assess the impact of different hs-CRP levels on baPWV≥1,400 cm/s.
Results: (1) After a mean follow-up of 5.12 ± 2.84 years, the detection rates of baPWV≥1,400 cm/s at the end of follow-up were 28.54%, 33.36%, and 36.25% in the hs-CRP<1 mg/L (n=5,998), 1 mg/L≤ hs-CRP≤3 mg/L (n=4,101), and hs-CRP>3 mg/L (n=1,578) groups, respectively (P<0.001). (2) Multivariable-adjusted Poisson regression analysis for baPWV≥1,400 cm/s showed that, after adjusting for confounding factors, compared to the hs-CRP<1 mg/L group, the 1 mg/L≤hs-CRP≤3 mg/L group had a 2.4% higher risk of arterial stiffness (RR: 1.024; 95% CI: 1.002 to 1.047; P<0.05) and hs-CRP>3 mg/L group had a 6.3% higher risk (RR: 1.063; 95% CI: 1.031 to 1.095; P<0.001). Sensitivity analysis validated the robustness of the results.
Conclusion: Elevated hs-CRP is an independent risk factor for arteriosclerosis progression.
期刊介绍：
An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
