铜(I)催化二芳基膦硫化物与醛胺的不对称加成反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-01 DOI:10.1039/d5ob00682a

Dong-Liang Xie , Hu Tian , Liang Yin

引用次数: 0

摘要

在这里，我们报道了铜(I)催化的二芳基膦硫化物对n -硫代膦酰醛胺的对映选择性加成。该反应具有条件温和、操作简单、对映体选择性高等优点。对照实验表明，在二芳基膦硫化物和n -硫代膦酰醛胺中，铜(I)催化剂与硫原子之间的“软软”相互作用促进了加成反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper(i)-catalyzed asymmetric addition of diarylphosphine sulfides to aldimines†

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Copper(i)-catalyzed asymmetric addition of diarylphosphine sulfides to aldimines†

Herein, we report a copper(i)-catalyzed enantioselective addition of diarylphosphine sulfides to N-thiophosphinoyl aldimines. The reaction offers some advantages, such as mild conditions, an easy protocol, and high enantioselectivity. Control experiments indicate that the “soft–soft” interactions between the copper(i) catalyst and the sulfur atoms in both diarylphosphine sulfides and N-thiophosphinoyl aldimines facilitate the addition.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.