全球地衣全息生物合成与分类图谱

IF 4 2区 生物学 Q2 MICROBIOLOGY
Samantha C. Waterworth, Susan Egbert, John Sorensen, Barry R. O'Keefe, John A. Beutler
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引用次数: 0

摘要

地衣是几个生态系统中的先驱物种,因此在各种地理区域和环境中都有发现。在这里,对来自34个国家的794份地衣样本的宏基因组数据的检查显示,存在一种复杂的全息生物,具有非凡的生物合成能力,特别是在细菌联合体中,这一成分在某种程度上被低估了。虽然细菌一直存在,但它们的丰度在地衣分类群中有所不同。常见的细菌属包括Microbacterium、Terribacillus和JABEUN01(一种有待拉丁二名命名的酸化微生物科细菌),尽管丰度较低。Lichenihabitans和鞘单胞菌属的数量适中,约占样品的30%,并且在预测编码次级代谢物(生物合成潜力)的生物合成基因簇(bgc)数量中表现出富集。我们发现真菌和细菌的生物合成谱似乎都遵循属特异性模式,但真菌属中bgc的相对同质性更大。在我们的发现中,地衣全息生物体内的大量生物合成多样性是显而易见的,地衣相关细菌正在成为可持续药物发现的有希望的潜在来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

Lichens are pioneer species in several ecosystems, and as such are found in a variety of geographic regions and environments. Here, inspection of metagenomic data from 794 lichen samples from 34 countries reveals the presence of a complex holobiont harbouring remarkable biosynthetic capabilities, particularly in the bacterial consortia, a component that has been somewhat underappreciated. While bacteria were consistently present, their abundance varied among lichen taxa. Common bacterial genera included Microbacterium, Terribacillus, and JABEUN01 (an Acidimicrobiaceae bacterium awaiting Latin binomial naming assignment) albeit in low abundance. Lichenihabitans and Sphingomonas genera were moderately abundant, present in approximately 30% of samples, and exhibited an enrichment in the number of biosynthetic gene clusters (BGCs) predicted to encode secondary metabolites (biosynthetic potential). We found that both fungal and bacterial biosynthetic repertoires appeared to follow genus-specific patterns but that there was greater relative homogeneity of BGCs in the fungal genera. The substantial biosynthetic diversity within lichen holobionts is evident in our findings, with the lichen-associated bacteria emerging as a promising potential source for sustainable drug discovery.

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来源期刊
Environmental microbiology
Environmental microbiology 环境科学-微生物学
CiteScore
9.90
自引率
3.90%
发文量
427
审稿时长
2.3 months
期刊介绍: Environmental Microbiology provides a high profile vehicle for publication of the most innovative, original and rigorous research in the field. The scope of the Journal encompasses the diversity of current research on microbial processes in the environment, microbial communities, interactions and evolution and includes, but is not limited to, the following: the structure, activities and communal behaviour of microbial communities microbial community genetics and evolutionary processes microbial symbioses, microbial interactions and interactions with plants, animals and abiotic factors microbes in the tree of life, microbial diversification and evolution population biology and clonal structure microbial metabolic and structural diversity microbial physiology, growth and survival microbes and surfaces, adhesion and biofouling responses to environmental signals and stress factors modelling and theory development pollution microbiology extremophiles and life in extreme and unusual little-explored habitats element cycles and biogeochemical processes, primary and secondary production microbes in a changing world, microbially-influenced global changes evolution and diversity of archaeal and bacterial viruses new technological developments in microbial ecology and evolution, in particular for the study of activities of microbial communities, non-culturable microorganisms and emerging pathogens
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