镁可吸收膜引导兔临界尺寸骨缺损模型骨再生-组织形态学分析

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Implant Dentistry and Related Research Pub Date : 2025-06-05 DOI:10.1111/cid.70055

Ilan Beitlitum, Fatma Rayyan, Gil Slutzkey, Perry Raz, Rachel Sarig

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引用次数: 0

摘要

目的探讨镁基膜在兔颅骨引导骨再生中的作用。材料与方法9只兔每只颅骨上有4个临界大小的缺损，随机填充血凝块或牛异种移植物。一侧覆盖mg基膜，对照组不覆盖膜。8周后，进行组织形态学分析，比较新骨与原始骨的形成情况。结果Mg-supported membrane for guided bone regeneration （GBR）是安全的，并能促进兔颅骨临界尺寸缺损（CSD）的骨形成。由于膜降解，在三分之一的标本中观察到气体积聚。组织形态学分析显示，与血凝块（2.14±2.22 mm2）相比，Mg膜移植缺损的骨形成（4.85±1.73 mm2）更大。用填充物或镁膜治疗病变导致所有三个检查区域的骨形成明显增加（25%-62%）。在原有骨包膜外观察到新骨形成。结论镁基膜支持引导骨再生（GBR），当与骨移植物联合使用时，尽管膜降解会导致气体积聚，但仍能提高其性能。关于mg基膜在GBR中的应用及其对骨形成的影响的数据有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Magnesium Resorbable Membrane for Guided Bone Regeneration in Critical Size Defect Model in Rabbits—Histomorphometric Analysis

Objectives

To evaluate the effectiveness of a Mg-based membrane as a barrier for guided bone regeneration in rabbits calvaria.

Materials and Methods

Nine rabbits had four critical size defects created in each calvarium, randomly filled with a blood clot or bovine xenograft. One side was covered with the Mg-based membrane, and the control was left without membrane. After 8 weeks, histomorphometric analysis was performed to compare new bone formation with the pristine bone.

Results

Mg-supported membrane for guided bone regeneration (GBR) is safe and promotes bone formation in critical size defects (CSD) in a rabbit calvaria. Gas accumulation was observed in a third of the specimens due to membrane degradation. Histomorphometric analysis revealed greater bone formation in the defects grafted with the Mg membrane (4.85 ± 1.73 mm²) compared to the blood clot (2.14 ± 2.22 mm²). Treating lesions with filler or the magnesium membrane resulted in significantly higher bone formation in all three examined regions (25%–62%). New bone formation was observed beyond the original bone envelope.

Conclusion

Mg-based membrane supports guided bone regeneration (GBR), and when used in combination with a bone graft, enhances the performance despite the gas accumulation associated with membrane degradation.

Clinical Relevance

Limited data exist on the use of Mg-based membranes in GBR and its effect on bone formation.

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.