滤泡调节性t细胞在神经免疫疾病中的新作用

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-06-04 DOI:10.1016/j.coi.2025.102584

Stephen Opoku , Qisen Guo , Jianmei W Leavenworth

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引用次数: 0

摘要

免疫耐受是防止自我伤害的关键，同时保持有效的免疫反应对抗外来的伤害。这种平衡的破坏会导致自身免疫和炎症状况，包括以神经系统异常炎症为特征的神经免疫疾病。滤泡调节性T细胞（滤泡调节性T细胞）是调节性T细胞（Treg）的一个特殊亚群，在控制体液免疫中发挥重要作用，适当调节对外来抗原的高亲和力抗体反应，同时限制自身反应性抗体的产生。除了这个被充分证明的作用，最近的研究揭示了它的组织特异性调节以及组织Treg细胞的新发现。在这篇综述中，我们将重点关注目前对TFR细胞的理解，并通过强调这些细胞在疾病进展调节中的异质性和可塑性，讨论这些细胞在神经免疫疾病中的新发现。

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Emerging role of follicular regulatory T-cells in neuroimmunological disorders

Immune tolerance is essential for preventing self-damage while maintaining effective immune responses against foreign insults. Disruptions in this balance contribute to autoimmune and inflammatory conditions, including neuroimmunological disorders that are characterized by aberrant inflammation in the nervous system. Follicular regulatory T (T_FR) cells, a specialized subset of regulatory T (Treg) cells, play important roles in the control of humoral immunity, properly regulating high-affinity antibody responses to foreign antigens while limiting autoreactive antibody production. Beyond this well-documented role, recent studies have revealed its tissue-specific regulation along with the new discoveries of tissue Treg cells. In this review, we focus on the current understanding of T_FR cells and discuss the emerging findings of these cells in neuroimmunological disorders by highlighting their heterogeneity and plasticity in the regulation of disease progression.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.