2012-2021年马提尼克岛宫颈癌负担

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-06-04 DOI:10.1016/j.canep.2025.102857

Rémi Houpert , Emmanuelle Sylvestre , Anne-Déborah Bouhnik , Marc-Karim Ben-Diane , Fatiha Najioullah , Thierry Almont , Wendy Boutant , Jonathan Macni , Julien Mancini , Clarisse Joachim , Jacqueline Veronique-Baudin

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引用次数: 0

摘要

目的提供2012年至2021年法属加勒比地区宫颈癌发病率、死亡率和生存率的负担和时间趋势的最新概述。方法本回顾性研究纳入了2012年至2021年间在马提尼克岛人口癌症登记处诊断和登记的所有宫颈癌病例。数据严格按照国际癌症研究机构、法国和欧洲癌症登记网络制定的国际标准进行记录。对侵袭性病例进行描述性流行病学分析和生存分析。我们使用世界卫生组织标准世界人口计算世界年龄标准化发病率和死亡率。总生存率为95% %置信区间，计算为从诊断到任何原因死亡的时间。在最后一次随访日期或截止日期2023年12月31日对患者进行审查。我们使用Kaplan-Meier产品极限法估计1年、3年、5年和10年的总生存率。结果在研究期间，原位肿瘤1196例，侵袭性肿瘤202例。45.0 % 65岁及以上的女性，67.3% %接受化疗和/或放疗。大多数侵袭性病例诊断为局部晚期（43.1% %），鳞状细胞癌（75.2% %）。世界年龄标准化发病率和死亡率的趋势在全球范围内保持不变，分别为每10万人年6例和每10万人年3例。5年总生存率为51.4% %(44.2% %；58.1% %)，10年为41.8 %(33.8 %；49.6 %)。结论：在这项回顾性队列研究中，来自合格癌症登记处的数据全面描述了加勒比地区宫颈癌的负担。这些发现对于规划、监测和评估国家疫苗接种、筛查和治疗措施的持续影响至关重要，这些措施是在这些特别高负担地区大力促进消除宫颈癌所必需的。

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Burden of cervical cancer in Martinique, 2012–2021

Objective

To provide an updated overview of the burden and temporal trends in incidence, mortality and survival of cervical cancer in a French Caribbean region between 2012 and 2021.

Methods

This retrospective study included all cases of cervical cancer diagnosed and registered by the Martinique Population-Based Cancer Registry between 2012 and 2021. Data were recorded strictly according to international standards set by the International Agency for Research on Cancer, French and European Network of Cancer Registries. A descriptive epidemiological analysis and a survival analysis for invasive cases were performed. We calculated world age-standardized incidence and mortality rates, using the WHO standard world population. Overall survival, with a 95 % confidence interval, was calculated as the time from diagnosis to death from any cause. Patients were censored at the date of last follow-up or at the cut-off date of December 31, 2023. We used the Kaplan-Meier product limit method to estimate overall survival at 1, 3, 5 and 10 years.

Results

Over the study period, 1196 in situ tumors and 202 invasive cases were diagnosed. 45.0 % of women were aged 65 and over, and 67.3 % received chemotherapy and/or radiotherapy. Most invasive cases were diagnosed with locally advanced stage (43.1 %) and were squamous cell carcinomas (75.2 %). Trends in world age-standardized incidence and mortality rates were globally constant at 6 per 100,000 and 3 per 100,000 person-years, respectively. Overall survival at 5 years was 51.4 % (44.2 %; 58.1 %), and at 10 years, 41.8 % (33.8 %; 49.6 %).

Conclusions

In this retrospective cohort study, data from a qualified cancer registry comprehensively described the burden of cervical cancer in a Caribbean region. These findings are essential for planning, monitoring, and evaluating the ongoing impact of the national vaccination, screening, and treatment measures required to drastically contribute to the elimination of cervical cancer in these particularly high-burden regions.

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.