Key genes in the Hippo-YAP pathway: Implications for cervical cancer

One of the leading causes of cancer-related deaths globally is cervical cancer, which has many molecular mechanisms associated with its pathophysiology, including the dysfunction of the Hippo-YAP signalling system. The route can affect important biological processes such as cell growth, division, and survival. Risk factors for cervical cancer include long-term use of oral contraceptives, early sexual activity, multiple sexual partners, human papillomavirus infection, and cervical intraepithelial neoplasia. The disease mechanisms are regulated by many genes such as EGFR, MYC, CCND1, and ERBB2. The Hippo signalling pathway phosphorylates YAP/TAZ, thereby inhibiting carcinogenic potential. Dysregulation of the pathway has been linked with poor prognosis, lymph node metastasis, and cervical carcinoma in the early stage through YAP/TAZ activation. Progress in sequencing technologies, such as transcriptomics, single-cell genomic profiling, and multi-omics integration, has also shed light on this pathway for setting the foundation for better treatment. Vaccination against HPVs with high rates and intensive screening programs are critical for reducing cervical cancer incidence and death reduction. This review analyzed cervical cancer pathogenic genes and gene expression profiles by the Hippo-YAP pathway, with a comprehensive discussion of pathophysiology, progression, and drug resistance.