{"title":"大鼠新型肌肉损伤的治疗","authors":"Jorge Ferreira","doi":"10.1038/s41684-025-01563-y","DOIUrl":null,"url":null,"abstract":"<p>Muscle injuries are common in sports and daily life, involving inflammation, regeneration and remodeling of muscle tissue. A study in <i>Scientific Reports</i> evaluated the effects of two subtypes of platelet-rich plasma (PRP), the leukocyte-poor PRP (LP-PRP) and the leukocyte-rich PRP (LR-PRP), and the peptide antagonist of the domains 1 and 2 of the IL-1β receptor (DAP1-2) on inflammation following muscle contusion in Wistar rats. Treatment with LP-PRP and DAP1-2, individually or combined, showed the most significant effects. Notably, RT-qPCR and ELISA showed a modulation of early inflammation markers compared to the control injury group and that the treatment promotes an efficient transition from the initial inflammation stage to tissue regeneration. However, the study endpoint was five days post-injury, limiting insights into long-term effects. The combined use of LP-PRP and IL-1β inhibitor peptides may represent a novel therapeutic strategy for acute muscle injuries, but further research is needed to confirm efficacy and understand mechanisms of action.</p><p><b>Original reference:</b> Colares, M.C. et al. <i>Sci. Rep</i>. <b>15</b>, 14219 (2025)</p>","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"8 1","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel muscle injury treatment in rats\",\"authors\":\"Jorge Ferreira\",\"doi\":\"10.1038/s41684-025-01563-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Muscle injuries are common in sports and daily life, involving inflammation, regeneration and remodeling of muscle tissue. A study in <i>Scientific Reports</i> evaluated the effects of two subtypes of platelet-rich plasma (PRP), the leukocyte-poor PRP (LP-PRP) and the leukocyte-rich PRP (LR-PRP), and the peptide antagonist of the domains 1 and 2 of the IL-1β receptor (DAP1-2) on inflammation following muscle contusion in Wistar rats. Treatment with LP-PRP and DAP1-2, individually or combined, showed the most significant effects. Notably, RT-qPCR and ELISA showed a modulation of early inflammation markers compared to the control injury group and that the treatment promotes an efficient transition from the initial inflammation stage to tissue regeneration. However, the study endpoint was five days post-injury, limiting insights into long-term effects. The combined use of LP-PRP and IL-1β inhibitor peptides may represent a novel therapeutic strategy for acute muscle injuries, but further research is needed to confirm efficacy and understand mechanisms of action.</p><p><b>Original reference:</b> Colares, M.C. et al. <i>Sci. Rep</i>. <b>15</b>, 14219 (2025)</p>\",\"PeriodicalId\":17936,\"journal\":{\"name\":\"Lab Animal\",\"volume\":\"8 1\",\"pages\":\"\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lab Animal\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1038/s41684-025-01563-y\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lab Animal","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1038/s41684-025-01563-y","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Muscle injuries are common in sports and daily life, involving inflammation, regeneration and remodeling of muscle tissue. A study in Scientific Reports evaluated the effects of two subtypes of platelet-rich plasma (PRP), the leukocyte-poor PRP (LP-PRP) and the leukocyte-rich PRP (LR-PRP), and the peptide antagonist of the domains 1 and 2 of the IL-1β receptor (DAP1-2) on inflammation following muscle contusion in Wistar rats. Treatment with LP-PRP and DAP1-2, individually or combined, showed the most significant effects. Notably, RT-qPCR and ELISA showed a modulation of early inflammation markers compared to the control injury group and that the treatment promotes an efficient transition from the initial inflammation stage to tissue regeneration. However, the study endpoint was five days post-injury, limiting insights into long-term effects. The combined use of LP-PRP and IL-1β inhibitor peptides may represent a novel therapeutic strategy for acute muscle injuries, but further research is needed to confirm efficacy and understand mechanisms of action.
Original reference: Colares, M.C. et al. Sci. Rep. 15, 14219 (2025)
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