{"title":"外耳道癌11种分期的比较。","authors":"Aniwat Berpan","doi":"10.1007/s00405-025-09489-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>To compare overall survival (OS) differences across 11 different staging classifications.</p><p><strong>Materials and methods: </strong>Patient data were retrospectively collected. OS curves were estimated by Kaplan-Meier method. Hazard ratios (HR) were calculated by Cox regression. Concordance between HR of each system was evaluated by C-index. Absolute net reclassification improvement (NRI) was performed.</p><p><strong>Results: </strong>Thirty-five patients fitted study criteria with median follow-up of 27.3 months. 80% were diagnosed with squamous cell carcinoma. 14.3% had ECOG > 1. Eighteen patients underwent surgery, while 31 patients received radiotherapy. For AJCC 8th edition cutaneous carcinoma of the head and neck, 3-year OS of stage 1-3 and 4 was 26.7% (median OS of 0.8 years) and 64.1% (median OS of 4.3 years) (HR 0.33; 95%CI 0.09-1.2). 3-year OS of T1-3 and T4 in modified Pittsburgh classification were 65% and 55.4% with median OS of not reached and 3.1 years (HR 1.86; 95%CI 0.66-5.23). Regarding Kinney system, patients with stage 1-2 and 3 had 3-year OS of 67.1% and 45.5%, while median OS was 4.7 years and 1 year (HR 1.94; 95%CI 0.75-4.97). C-indices were 0.577, 0.523 and 0.569. NRI comparing Kinney with modified Pittsburgh classifications was 2.86%.</p><p><strong>Conclusion: </strong>Kinney's may offer improved prognostic accuracy compared to other classifications.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of 11 staging classifications in carcinoma of the external auditory canal.\",\"authors\":\"Aniwat Berpan\",\"doi\":\"10.1007/s00405-025-09489-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>To compare overall survival (OS) differences across 11 different staging classifications.</p><p><strong>Materials and methods: </strong>Patient data were retrospectively collected. OS curves were estimated by Kaplan-Meier method. Hazard ratios (HR) were calculated by Cox regression. Concordance between HR of each system was evaluated by C-index. Absolute net reclassification improvement (NRI) was performed.</p><p><strong>Results: </strong>Thirty-five patients fitted study criteria with median follow-up of 27.3 months. 80% were diagnosed with squamous cell carcinoma. 14.3% had ECOG > 1. Eighteen patients underwent surgery, while 31 patients received radiotherapy. For AJCC 8th edition cutaneous carcinoma of the head and neck, 3-year OS of stage 1-3 and 4 was 26.7% (median OS of 0.8 years) and 64.1% (median OS of 4.3 years) (HR 0.33; 95%CI 0.09-1.2). 3-year OS of T1-3 and T4 in modified Pittsburgh classification were 65% and 55.4% with median OS of not reached and 3.1 years (HR 1.86; 95%CI 0.66-5.23). Regarding Kinney system, patients with stage 1-2 and 3 had 3-year OS of 67.1% and 45.5%, while median OS was 4.7 years and 1 year (HR 1.94; 95%CI 0.75-4.97). C-indices were 0.577, 0.523 and 0.569. NRI comparing Kinney with modified Pittsburgh classifications was 2.86%.</p><p><strong>Conclusion: </strong>Kinney's may offer improved prognostic accuracy compared to other classifications.</p>\",\"PeriodicalId\":520614,\"journal\":{\"name\":\"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00405-025-09489-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00405-025-09489-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison of 11 staging classifications in carcinoma of the external auditory canal.
Background and purpose: To compare overall survival (OS) differences across 11 different staging classifications.
Materials and methods: Patient data were retrospectively collected. OS curves were estimated by Kaplan-Meier method. Hazard ratios (HR) were calculated by Cox regression. Concordance between HR of each system was evaluated by C-index. Absolute net reclassification improvement (NRI) was performed.
Results: Thirty-five patients fitted study criteria with median follow-up of 27.3 months. 80% were diagnosed with squamous cell carcinoma. 14.3% had ECOG > 1. Eighteen patients underwent surgery, while 31 patients received radiotherapy. For AJCC 8th edition cutaneous carcinoma of the head and neck, 3-year OS of stage 1-3 and 4 was 26.7% (median OS of 0.8 years) and 64.1% (median OS of 4.3 years) (HR 0.33; 95%CI 0.09-1.2). 3-year OS of T1-3 and T4 in modified Pittsburgh classification were 65% and 55.4% with median OS of not reached and 3.1 years (HR 1.86; 95%CI 0.66-5.23). Regarding Kinney system, patients with stage 1-2 and 3 had 3-year OS of 67.1% and 45.5%, while median OS was 4.7 years and 1 year (HR 1.94; 95%CI 0.75-4.97). C-indices were 0.577, 0.523 and 0.569. NRI comparing Kinney with modified Pittsburgh classifications was 2.86%.
Conclusion: Kinney's may offer improved prognostic accuracy compared to other classifications.