Awais Farid, Wei Han, Christopher K C Lai, Joseph K C Kwan, King Lun Yeung
{"title":"MAP-1抗菌涂层在患者隐私窗帘上的临床评价：来自香港一家医院随机试验的见解","authors":"Awais Farid, Wei Han, Christopher K C Lai, Joseph K C Kwan, King Lun Yeung","doi":"10.1016/j.jhin.2025.05.012","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Microorganisms, including multidrug-resistant organisms (MDROs), can persist on hospital surfaces, posing significant health risks. Patient privacy curtains (PPCs) are particularly vulnerable due to their porous nature, serving as potential reservoirs for pathogens.</p><p><strong>Aim: </strong>This study evaluates the effectiveness of a multilevel antimicrobial polymer (MAP-1) coating on PPCs in reducing microbial loads, including MRSA. The objective is to determine its potential in lowering bacterial contamination and mitigating hospital-acquired infections (HAIs).</p><p><strong>Methods: </strong>A cross-over, randomized, double-blind clinical trial was conducted in male and female cubicles of a Hong Kong rehabilitation ward. 1,824 samples compared mean microbial load on MAP-1-coated PPCs to standard laundered PPCs on 76 patient bed curtains (patients aged 18-99 with stays >48 hours). The primary outcome measured was the percentage reduction in bacterial counts on treated versus untreated PPCs across three 4-week phases, with secondary outcomes on staff feedback.</p><p><strong>Findings: </strong>MAP-1 coated PPCs showed a 96.8% reduction in total viable bacteria (p < 0.00001; 95% CI, 94.8-98.2%) and 99.3% in MRSA (p < 0.00001; 95% CI, 97.4-99.5%) compared with uncoated PPCs. Effectiveness was maintained over all 4-week periods, consistently reducing bacteria and MRSA by over 95%. Staff feedback indicated strong acceptance of the technology for routine use.</p><p><strong>Conclusion: </strong>The MAP-1 coating demonstrated high efficacy in reducing pathogen presence on PPCs, with sustained effectiveness suggesting its potential for long-term application in hospital settings.</p><p><strong>Clinical trial registry: </strong>NCT03795090.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Evaluation of MAP-1 Antimicrobial Coating on Patient Privacy Curtains: Insights from a Randomized Trial in a Hong Kong Hospital.\",\"authors\":\"Awais Farid, Wei Han, Christopher K C Lai, Joseph K C Kwan, King Lun Yeung\",\"doi\":\"10.1016/j.jhin.2025.05.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Microorganisms, including multidrug-resistant organisms (MDROs), can persist on hospital surfaces, posing significant health risks. Patient privacy curtains (PPCs) are particularly vulnerable due to their porous nature, serving as potential reservoirs for pathogens.</p><p><strong>Aim: </strong>This study evaluates the effectiveness of a multilevel antimicrobial polymer (MAP-1) coating on PPCs in reducing microbial loads, including MRSA. The objective is to determine its potential in lowering bacterial contamination and mitigating hospital-acquired infections (HAIs).</p><p><strong>Methods: </strong>A cross-over, randomized, double-blind clinical trial was conducted in male and female cubicles of a Hong Kong rehabilitation ward. 1,824 samples compared mean microbial load on MAP-1-coated PPCs to standard laundered PPCs on 76 patient bed curtains (patients aged 18-99 with stays >48 hours). The primary outcome measured was the percentage reduction in bacterial counts on treated versus untreated PPCs across three 4-week phases, with secondary outcomes on staff feedback.</p><p><strong>Findings: </strong>MAP-1 coated PPCs showed a 96.8% reduction in total viable bacteria (p < 0.00001; 95% CI, 94.8-98.2%) and 99.3% in MRSA (p < 0.00001; 95% CI, 97.4-99.5%) compared with uncoated PPCs. Effectiveness was maintained over all 4-week periods, consistently reducing bacteria and MRSA by over 95%. 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Clinical Evaluation of MAP-1 Antimicrobial Coating on Patient Privacy Curtains: Insights from a Randomized Trial in a Hong Kong Hospital.
Background: Microorganisms, including multidrug-resistant organisms (MDROs), can persist on hospital surfaces, posing significant health risks. Patient privacy curtains (PPCs) are particularly vulnerable due to their porous nature, serving as potential reservoirs for pathogens.
Aim: This study evaluates the effectiveness of a multilevel antimicrobial polymer (MAP-1) coating on PPCs in reducing microbial loads, including MRSA. The objective is to determine its potential in lowering bacterial contamination and mitigating hospital-acquired infections (HAIs).
Methods: A cross-over, randomized, double-blind clinical trial was conducted in male and female cubicles of a Hong Kong rehabilitation ward. 1,824 samples compared mean microbial load on MAP-1-coated PPCs to standard laundered PPCs on 76 patient bed curtains (patients aged 18-99 with stays >48 hours). The primary outcome measured was the percentage reduction in bacterial counts on treated versus untreated PPCs across three 4-week phases, with secondary outcomes on staff feedback.
Findings: MAP-1 coated PPCs showed a 96.8% reduction in total viable bacteria (p < 0.00001; 95% CI, 94.8-98.2%) and 99.3% in MRSA (p < 0.00001; 95% CI, 97.4-99.5%) compared with uncoated PPCs. Effectiveness was maintained over all 4-week periods, consistently reducing bacteria and MRSA by over 95%. Staff feedback indicated strong acceptance of the technology for routine use.
Conclusion: The MAP-1 coating demonstrated high efficacy in reducing pathogen presence on PPCs, with sustained effectiveness suggesting its potential for long-term application in hospital settings.
期刊介绍：
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.
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