{"title":"68Ga-DOTA TOC PET-CT显示脑膜瘤伴骨浸润的分子研究进展。","authors":"Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Syed Furqan Hashmi, Jamsari Khalid, Subhash Kheruka","doi":"10.4274/mirt.galenos.2024.99267","DOIUrl":null,"url":null,"abstract":"<p><p>Meningiomas express the somatostatin receptor (SSTR). The utilization of SSTR ligands, specifically Gallium-68 (<sup>68</sup>Ga) isotope, a radioactive isotope (<sup>68</sup>Ga)-DOTA-labeled peptides, has demonstrated exceptional diagnostic precision for the detection of meningiomas, primarily due to the absence of normal brain and bone activity. We report a case of a 48-year-old woman with sphenoid wing meningioma who underwent <sup>68</sup>Ga-DOTA TOC positron emission tomography (PET) for tumor delineation. <sup>68</sup>Ga-DOTA TOC PET shows SSTR-avid meningioma in the right sphenoid/anterior temporal region with significant hyperostosis with high expression of SSTR in the bone. <sup>68</sup>Ga-DOTA TOC uptake in the hyperostosis signifies bone infiltration rather than reactive changes. <sup>68</sup>Ga-DOTA PET provides a better assessment of osseous involvement and provides additional information in terms of meningioma extent and planning for further management.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 2","pages":"152-155"},"PeriodicalIF":1.1000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134966/pdf/","citationCount":"0","resultStr":"{\"title\":\"Molecular Perspectives on Meningioma with Osseous Infiltration Revealed by <sup>68</sup>Ga-DOTA TOC PET-CT.\",\"authors\":\"Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Syed Furqan Hashmi, Jamsari Khalid, Subhash Kheruka\",\"doi\":\"10.4274/mirt.galenos.2024.99267\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Meningiomas express the somatostatin receptor (SSTR). The utilization of SSTR ligands, specifically Gallium-68 (<sup>68</sup>Ga) isotope, a radioactive isotope (<sup>68</sup>Ga)-DOTA-labeled peptides, has demonstrated exceptional diagnostic precision for the detection of meningiomas, primarily due to the absence of normal brain and bone activity. We report a case of a 48-year-old woman with sphenoid wing meningioma who underwent <sup>68</sup>Ga-DOTA TOC positron emission tomography (PET) for tumor delineation. <sup>68</sup>Ga-DOTA TOC PET shows SSTR-avid meningioma in the right sphenoid/anterior temporal region with significant hyperostosis with high expression of SSTR in the bone. <sup>68</sup>Ga-DOTA TOC uptake in the hyperostosis signifies bone infiltration rather than reactive changes. <sup>68</sup>Ga-DOTA PET provides a better assessment of osseous involvement and provides additional information in terms of meningioma extent and planning for further management.</p>\",\"PeriodicalId\":44681,\"journal\":{\"name\":\"Molecular Imaging and Radionuclide Therapy\",\"volume\":\"34 2\",\"pages\":\"152-155\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134966/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Imaging and Radionuclide Therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4274/mirt.galenos.2024.99267\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Imaging and Radionuclide Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/mirt.galenos.2024.99267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Molecular Perspectives on Meningioma with Osseous Infiltration Revealed by 68Ga-DOTA TOC PET-CT.
Meningiomas express the somatostatin receptor (SSTR). The utilization of SSTR ligands, specifically Gallium-68 (68Ga) isotope, a radioactive isotope (68Ga)-DOTA-labeled peptides, has demonstrated exceptional diagnostic precision for the detection of meningiomas, primarily due to the absence of normal brain and bone activity. We report a case of a 48-year-old woman with sphenoid wing meningioma who underwent 68Ga-DOTA TOC positron emission tomography (PET) for tumor delineation. 68Ga-DOTA TOC PET shows SSTR-avid meningioma in the right sphenoid/anterior temporal region with significant hyperostosis with high expression of SSTR in the bone. 68Ga-DOTA TOC uptake in the hyperostosis signifies bone infiltration rather than reactive changes. 68Ga-DOTA PET provides a better assessment of osseous involvement and provides additional information in terms of meningioma extent and planning for further management.
期刊介绍：
Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.
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