Marta Zerunian, Benedetta Masci, Dominga Pugliese, Stefano Nardacci, Michela Polici, Francesco Pucciarelli, Domenico De Santis, Damiano Caruso, Giacinto La Verde, Andrea Laghi
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According to MY-RADS guideline, bone lesion with ADC values 700-1400 µm<sup>2</sup>/sec was considered malignant and regions of interests (ROIs) were placed in bone lesions and healthy bone marrow. Both malignant lesions and healthy bone ADC3b were compared with ADC2b, considering as significant p < 0.05. In case of discordant ROIs on the two ADC maps for malignity/benignity, expert radiologists examined all the WB-MRI sequences to assign a malignant/benign qualitative assessment.</p><p><strong>Results: </strong>Fifty-five patients (25 females, 29-83 yo) were retrospectively included; 305 bone lesions and 303 healthy bone segments were assessed. Objective analysis showed different ADC values between bone lesions' in ADC3b and ADC2b (965.3 ± 216.7 µm<sup>2</sup>/sec vs 937.2 ± 218.8 µm<sup>2</sup>/sec, p < 0.0001) and in healthy bone marrow ROIs (588 ± 271.7 vs 573.1 ± 573.1 ± 271.2, p < 0.0001). Despite significant differences, almost all the analyzed ROIs lay in the same range of ADC for bone lesions. 10/305 bone lesions fell into the range of malignity for ADC3b while showing lower values < 700 µm<sup>2</sup>/sec for ADC2b (ADC3b 715.82 ± 190.9 µm<sup>2</sup>/sec vs. ADC2b 687.72 ± 185.2 µm<sup>2</sup>/sec); focal bone lesion with discordant values was then confirmed as lesions, in accordance with ADC3b, by a panel of experts that blind-reviewed the whole sequences of the examinations.</p><p><strong>Conclusion: </strong>ADC2b is comparable with ADC3b except for borderline values (650-750 µm<sup>2</sup>/sec).</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ADC measurement in whole-body MRI for multiple myeloma: a three b-values vs. two b-values DWI comparison.\",\"authors\":\"Marta Zerunian, Benedetta Masci, Dominga Pugliese, Stefano Nardacci, Michela Polici, Francesco Pucciarelli, Domenico De Santis, Damiano Caruso, Giacinto La Verde, Andrea Laghi\",\"doi\":\"10.1007/s11547-025-02026-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To compare apparent diffusion coefficient (ADC) values in whole-body MRI (WB-MRI) reconstructed from diffusion-weighted imaging (DWI) with three b-values (50-500-1000 s/mm<sup>2</sup>) compared with two b-values (50-1000 s/mm<sup>2</sup>).</p><p><strong>Materials and methods: </strong>Patients with multiple myeloma who underwent 1.5 T WB-MRI were retrospectively included. 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引用次数: 0
摘要
目的：比较三个b值（50-500-1000 s/mm2）与两个b值（50-1000 s/mm2）重建的全身MRI （WB-MRI）的表观扩散系数（ADC）值。材料和方法：回顾性分析接受1.5 T WB-MRI检查的多发性骨髓瘤患者。排除标准是严重的运动伪影。检查包括轴向DWI三个b值（50-500-1000 s/mm2）；除b500 s/mm2外，用三个b值（ADC3b）和两个b值（ADC2b）重建ADC图。根据MY-RADS指南，ADC值为700-1400µm2/sec的骨病变被认为是恶性的，并将兴趣区（roi）放置在骨病变和健康骨髓中。结果：回顾性纳入55例患者（25例女性，29-83岁）；评估了305个骨病变和303个健康骨段。目的分析ADC3b与ADC2b骨病变的ADC值差异（965.3±216.7µm2/sec vs 937.2±218.8µm2/sec）， ADC2b的ADC值差异（ADC3b 715.82±190.9µm2/sec vs ADC2b 687.72±185.2µm2/sec）；然后，根据ADC3b，由专家小组对整个检查序列进行盲检，确认值不一致的局灶性骨病变为病变。结论：ADC2b与ADC3b除交界值（650-750µm2/sec）外具有可比性。
ADC measurement in whole-body MRI for multiple myeloma: a three b-values vs. two b-values DWI comparison.
Purpose: To compare apparent diffusion coefficient (ADC) values in whole-body MRI (WB-MRI) reconstructed from diffusion-weighted imaging (DWI) with three b-values (50-500-1000 s/mm2) compared with two b-values (50-1000 s/mm2).
Materials and methods: Patients with multiple myeloma who underwent 1.5 T WB-MRI were retrospectively included. Exclusion criteria were severe motion artifacts. Examinations included axial DWI with three b-values (50-500-1000 s/mm2); ADC maps were reconstructed with both three values of b(ADC3b) and two values of b(ADC2b) excluding b500 s/mm2. According to MY-RADS guideline, bone lesion with ADC values 700-1400 µm2/sec was considered malignant and regions of interests (ROIs) were placed in bone lesions and healthy bone marrow. Both malignant lesions and healthy bone ADC3b were compared with ADC2b, considering as significant p < 0.05. In case of discordant ROIs on the two ADC maps for malignity/benignity, expert radiologists examined all the WB-MRI sequences to assign a malignant/benign qualitative assessment.
Results: Fifty-five patients (25 females, 29-83 yo) were retrospectively included; 305 bone lesions and 303 healthy bone segments were assessed. Objective analysis showed different ADC values between bone lesions' in ADC3b and ADC2b (965.3 ± 216.7 µm2/sec vs 937.2 ± 218.8 µm2/sec, p < 0.0001) and in healthy bone marrow ROIs (588 ± 271.7 vs 573.1 ± 573.1 ± 271.2, p < 0.0001). Despite significant differences, almost all the analyzed ROIs lay in the same range of ADC for bone lesions. 10/305 bone lesions fell into the range of malignity for ADC3b while showing lower values < 700 µm2/sec for ADC2b (ADC3b 715.82 ± 190.9 µm2/sec vs. ADC2b 687.72 ± 185.2 µm2/sec); focal bone lesion with discordant values was then confirmed as lesions, in accordance with ADC3b, by a panel of experts that blind-reviewed the whole sequences of the examinations.
Conclusion: ADC2b is comparable with ADC3b except for borderline values (650-750 µm2/sec).
期刊介绍：
Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.
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