川崎病患者血清基质金属蛋白酶和组织抑制剂的动态变化:对冠状动脉病变持续性的影响

IF 3.2 3区 医学 Q1 PEDIATRICS
Yaqi Li, Yao Lin, Chen Shen, Jing Zhang, Hui Wang, Qin Zhang, Lin Shi
{"title":"川崎病患者血清基质金属蛋白酶和组织抑制剂的动态变化:对冠状动脉病变持续性的影响","authors":"Yaqi Li, Yao Lin, Chen Shen, Jing Zhang, Hui Wang, Qin Zhang, Lin Shi","doi":"10.1186/s13052-025-01990-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The mechanism of coronary artery lesions (CALs) persistence in Kawasaki disease (KD) remains unclear. The study aimed to investigate the serum dynamic changes of matrix metalloproteinases (MPPs) and tissue inhibitors (TIMPs) in children with CALs caused by KD, and explore their correlation with short-term CAL outcomes.</p><p><strong>Methods: </strong>This is a nested case-control study. A total of 114 KD children with CALs completed the 3-month follow-up in discovery set and validation set. Children with CALs persisted after 3 months were enrolled as the CALs persistence group. The CALs regression group consisted of children with CALs regressed who were matched with each CALs persisted case by gender and age at a ratio of 2:1. In the discovery set, serum MMPs and TIMPs were measured using a Quantibody<sup>®</sup> Human MMP Array in febrile (before IVIG infusion) and defervescence phase (afebrile 48-72 h after initial treatment). Differential proteins between groups were identified by absolute logFC > 0.263 and adjust P value < 0.05. The findings were then validated in the independent validation set.</p><p><strong>Results: </strong>There were 8 (13.3%) KD children with CALs that persisted for 3 months in the discovery set, including 4 boys and 4 girls, with a median age of 3.00 years. In the febrile phase, there were no differences in MMPs and TIMPs between CALs persistence group and CALs regression group (P>0.05). After treatment, MMP-8 and MMP-9 decreased in both groups, while TIMP-1 was lower in CALs persistence group (P<0.05). Further validation study showed the same changes.</p><p><strong>Conclusions: </strong>MMPs and TIMPs have dynamic changes in children with CALs caused by KD. A low level of TIMP-1 after treatment may be related to CALs persistence, offering novel insights into the underlying mechanism.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"169"},"PeriodicalIF":3.2000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131489/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dynamic changes of serum matrix metalloproteinases and tissue inhibitors in Kawasaki disease: implications for coronary artery lesions persistence.\",\"authors\":\"Yaqi Li, Yao Lin, Chen Shen, Jing Zhang, Hui Wang, Qin Zhang, Lin Shi\",\"doi\":\"10.1186/s13052-025-01990-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The mechanism of coronary artery lesions (CALs) persistence in Kawasaki disease (KD) remains unclear. The study aimed to investigate the serum dynamic changes of matrix metalloproteinases (MPPs) and tissue inhibitors (TIMPs) in children with CALs caused by KD, and explore their correlation with short-term CAL outcomes.</p><p><strong>Methods: </strong>This is a nested case-control study. A total of 114 KD children with CALs completed the 3-month follow-up in discovery set and validation set. Children with CALs persisted after 3 months were enrolled as the CALs persistence group. The CALs regression group consisted of children with CALs regressed who were matched with each CALs persisted case by gender and age at a ratio of 2:1. In the discovery set, serum MMPs and TIMPs were measured using a Quantibody<sup>®</sup> Human MMP Array in febrile (before IVIG infusion) and defervescence phase (afebrile 48-72 h after initial treatment). Differential proteins between groups were identified by absolute logFC > 0.263 and adjust P value < 0.05. The findings were then validated in the independent validation set.</p><p><strong>Results: </strong>There were 8 (13.3%) KD children with CALs that persisted for 3 months in the discovery set, including 4 boys and 4 girls, with a median age of 3.00 years. In the febrile phase, there were no differences in MMPs and TIMPs between CALs persistence group and CALs regression group (P>0.05). After treatment, MMP-8 and MMP-9 decreased in both groups, while TIMP-1 was lower in CALs persistence group (P<0.05). Further validation study showed the same changes.</p><p><strong>Conclusions: </strong>MMPs and TIMPs have dynamic changes in children with CALs caused by KD. A low level of TIMP-1 after treatment may be related to CALs persistence, offering novel insights into the underlying mechanism.</p>\",\"PeriodicalId\":14511,\"journal\":{\"name\":\"Italian Journal of Pediatrics\",\"volume\":\"51 1\",\"pages\":\"169\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131489/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Italian Journal of Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13052-025-01990-0\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Italian Journal of Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13052-025-01990-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

摘要

背景:川崎病(KD)冠状动脉病变(CALs)持续的机制尚不清楚。本研究旨在探讨KD所致CALs患儿血清基质金属蛋白酶(MPPs)和组织抑制剂(TIMPs)的动态变化,并探讨其与短期CAL预后的相关性。方法:采用巢式病例对照研究。共有114名患有CALs的KD患儿完成了发现组和验证组3个月的随访。持续3个月的儿童被纳入CALs持续组。CALs回归组由患有CALs回归的儿童组成,他们按性别和年龄按2:1的比例与每个CALs持续病例匹配。在发现组中,使用Quantibody®Human MMP Array在发热期(IVIG输注前)和退热期(初始治疗后48-72小时)测量血清MMPs和TIMPs。结果:发现集中有8例(13.3%)KD患儿存在持续3个月的CALs,其中男4例,女4例,中位年龄3.00岁。发热期,CALs持续组与CALs回归组MMPs、TIMPs差异无统计学意义(P < 0.05)。治疗后,两组患者的MMP-8和MMP-9均降低,而CALs持续组的TIMP-1则降低(p结论:KD所致CALs患儿的MMPs和TIMPs存在动态变化。治疗后低水平的TIMP-1可能与CALs的持续有关,为其潜在机制提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamic changes of serum matrix metalloproteinases and tissue inhibitors in Kawasaki disease: implications for coronary artery lesions persistence.

Background: The mechanism of coronary artery lesions (CALs) persistence in Kawasaki disease (KD) remains unclear. The study aimed to investigate the serum dynamic changes of matrix metalloproteinases (MPPs) and tissue inhibitors (TIMPs) in children with CALs caused by KD, and explore their correlation with short-term CAL outcomes.

Methods: This is a nested case-control study. A total of 114 KD children with CALs completed the 3-month follow-up in discovery set and validation set. Children with CALs persisted after 3 months were enrolled as the CALs persistence group. The CALs regression group consisted of children with CALs regressed who were matched with each CALs persisted case by gender and age at a ratio of 2:1. In the discovery set, serum MMPs and TIMPs were measured using a Quantibody® Human MMP Array in febrile (before IVIG infusion) and defervescence phase (afebrile 48-72 h after initial treatment). Differential proteins between groups were identified by absolute logFC > 0.263 and adjust P value < 0.05. The findings were then validated in the independent validation set.

Results: There were 8 (13.3%) KD children with CALs that persisted for 3 months in the discovery set, including 4 boys and 4 girls, with a median age of 3.00 years. In the febrile phase, there were no differences in MMPs and TIMPs between CALs persistence group and CALs regression group (P>0.05). After treatment, MMP-8 and MMP-9 decreased in both groups, while TIMP-1 was lower in CALs persistence group (P<0.05). Further validation study showed the same changes.

Conclusions: MMPs and TIMPs have dynamic changes in children with CALs caused by KD. A low level of TIMP-1 after treatment may be related to CALs persistence, offering novel insights into the underlying mechanism.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.10
自引率
13.90%
发文量
192
审稿时长
6-12 weeks
期刊介绍: Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues. The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field. Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信