氨基酸和多肽在异氰酸酯存在下的c端脱羧酰胺化。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-06-13 Epub Date: 2025-06-02 DOI:10.1021/acs.joc.5c00143

Aman Singh Barahdia, Karuna Thakare, Rahul Jain

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引用次数: 0

摘要

末端修饰是发现新的肽类药物的一种有吸引力的策略。我们报道了DMAP催化氨基酸和多肽与异氰酸酯的反应，以快速和环境友好的方式合成了多种带有Boc， Fmoc或Cbz基团的c端或侧链修饰的氨基酸和多肽，并释放二氧化碳作为副产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Decarboxylative C-Terminus Amidation of Amino Acids and Peptides in the Presence of Isocyanates.

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Decarboxylative C-Terminus Amidation of Amino Acids and Peptides in the Presence of Isocyanates.

Termini modification is an attractive strategy for discovering new peptide-based drugs. We report that DMAP catalyzes the reaction of amino acids and peptides with isocyanates, synthesizing a variety of C-terminus or side chain modified amino acids and peptides bearing Boc, Fmoc, or Cbz groups in a rapid and environment-friendly manner and releasing CO₂ as a byproduct.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.