在红狐（Vulpes Vulpes）中出现了重组犬冠状病毒、小异瘟病毒和圆环病毒，这表明病毒在食肉动物中传播频繁

IF 3.5 2区农林科学 Q2 INFECTIOUS DISEASES

Transboundary and Emerging Diseases Pub Date : 2025-06-04 DOI:10.1155/tbed/6681119

Enikő Fehér, Gábor Kemenesi, Tamás Görföl, Yasmine Wazzani, Kornélia Bodó, József Lanszki, Dóra Máté, Eszter Kaszab, Marianna Domán, Zoltán Zádori, Zsófia Lanszki

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引用次数: 0

摘要

虽然它们的致病性通常不清楚，但已经发现一些犬病毒可以感染除狗以外的食肉动物。本研究依赖于对在匈牙利捕获的可狩猎的同域犬科动物和鼬科动物的206个唾液和粪便样本中的冠状病毒的监测，这些样本包括本地红狐（Vulpes Vulpes）、欧洲獾（Meles Meles）、金豺（Canis aureus）和石貂（Martes foina），以及最近定居的外来貉（Nyctereutes procyonoides）。采用基于宏基因组学和直接序列分析的方法，确定了从红狐采集的两个标本中鉴定出的冠状病毒的基因组序列。获得了两种犬冠状病毒（ccov）的近完整基因组序列，以及一种犬圆环病毒（CanineCV）的完整基因组序列和一种犬picodicistrovirus （CPDV）的近完整基因组序列。这提供了狐源冠状病毒和CPDV序列数据，以及CPDV在欧洲首次出现的记录。结果表明，重组在犬类和赤狐、金豺等野生食肉动物感染CCoV、CanineCV和CPDV的进化过程中具有重要意义。它们广泛分布于中欧和东南欧，范围很大，促进了多宿主犬病原体的传播。

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Occurrence of Recombinant Canine Coronavirus, Picodicistrovirus, and Circovirus in Red Foxes (Vulpes vulpes) Implies Frequent Virus Transmission Events Among Carnivores

Although their pathogenicity is most often unclear, some canine viruses have been found to infect carnivores other than dogs. This study relies on the surveillance of coronaviruses in 206 saliva and fecal samples of huntable, sympatric canid and mustelid species captured in Hungary, such as the native red fox (Vulpes vulpes), European badger (Meles meles), golden jackal (Canis aureus), and stone marten (Martes foina), as well as the recently settled alien raccoon dog (Nyctereutes procyonoides). Metagenomics-based and direct sequence analysis were deployed to determine the genome sequence of coronaviruses identified in two specimens collected from red foxes. Near-complete genome sequences of two canine coronaviruses (CCoVs) were obtained, together with the complete genome sequence of a canine circovirus (CanineCV) and the near-complete genome sequence of a canine picodicistrovirus (CPDV) from one of the samples. These provided the first fox origin CCoV and CPDV sequence data, and the first recorded appearance of the CPDV in Europe. The results suggested that recombination is of great importance in the evolution of CCoV, CanineCV, and CPDV infecting dogs and wild-living carnivores, including the red fox and golden jackal. These are widespread in Central and Southeast Europe, and have large ranges, facilitating transmission of the multihost canine pathogens.

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来源期刊

Transboundary and Emerging Diseases 农林科学-传染病学

CiteScore

8.90

自引率

9.30%

发文量

350

审稿时长

1 months

期刊介绍： Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions): Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread. Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope. Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies. Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies). Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.