聚电解质多层包埋的苯胺负载酪蛋白纳米球

IF 2.9 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Transactions on Dielectrics and Electrical Insulation Pub Date : 2025-02-24 DOI:10.1109/TDEI.2025.3542349

Asya Viraneva;Maria Marudova;Bissera Pilicheva;Aleksandar Grigorov;Nikolay Zahariev;Sofia Milenkova;Temenuzhka Yovcheva

{"title":"聚电解质多层包埋的苯胺负载酪蛋白纳米球","authors":"Asya Viraneva;Maria Marudova;Bissera Pilicheva;Aleksandar Grigorov;Nikolay Zahariev;Sofia Milenkova;Temenuzhka Yovcheva","doi":"10.1109/TDEI.2025.3542349","DOIUrl":null,"url":null,"abstract":"Polyelectrolyte multilayers (PEMs) films containing benzydamine hydrochloride (Benz)-loaded casein nanoparticles are developed aiming to increase the structure drug loading efficiency and to prolong the drug release. The multilayers are built on biodegradable polyester substrates, which are previously charged in a corona discharge. Medium viscosity sodium alginate (SA) is used as a partner in the multilayer formulation. The SA and the casein nanoparticles are deposited on the substrate using the layer-by-layer (LbL) deposition technique. The drug loading efficiency and the release kinetics in artificial saliva are determined spectrophotometrically.","PeriodicalId":13247,"journal":{"name":"IEEE Transactions on Dielectrics and Electrical Insulation","volume":"32 3","pages":"1599-1605"},"PeriodicalIF":2.9000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Benzydamine-Loaded Casein Nanospheres Embedded in Polyelectrolyte Multilayers\",\"authors\":\"Asya Viraneva;Maria Marudova;Bissera Pilicheva;Aleksandar Grigorov;Nikolay Zahariev;Sofia Milenkova;Temenuzhka Yovcheva\",\"doi\":\"10.1109/TDEI.2025.3542349\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Polyelectrolyte multilayers (PEMs) films containing benzydamine hydrochloride (Benz)-loaded casein nanoparticles are developed aiming to increase the structure drug loading efficiency and to prolong the drug release. The multilayers are built on biodegradable polyester substrates, which are previously charged in a corona discharge. Medium viscosity sodium alginate (SA) is used as a partner in the multilayer formulation. The SA and the casein nanoparticles are deposited on the substrate using the layer-by-layer (LbL) deposition technique. The drug loading efficiency and the release kinetics in artificial saliva are determined spectrophotometrically.\",\"PeriodicalId\":13247,\"journal\":{\"name\":\"IEEE Transactions on Dielectrics and Electrical Insulation\",\"volume\":\"32 3\",\"pages\":\"1599-1605\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-02-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Transactions on Dielectrics and Electrical Insulation\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://ieeexplore.ieee.org/document/10900544/\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Dielectrics and Electrical Insulation","FirstCategoryId":"5","ListUrlMain":"https://ieeexplore.ieee.org/document/10900544/","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

摘要

为了提高结构载药效率和延长药物释放时间，研制了含盐酸苄胺（Benz）纳米酪蛋白的聚电解质多层膜（PEMs）。多层材料是建立在可生物降解的聚酯基板上，在电晕放电中预先充电。中等粘度的海藻酸钠（SA）被用作多层配方中的合作伙伴。采用逐层沉积技术将SA和酪蛋白纳米颗粒沉积在衬底上。用分光光度法测定了该药物在人工唾液中的载药效率和释放动力学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Benzydamine-Loaded Casein Nanospheres Embedded in Polyelectrolyte Multilayers

Polyelectrolyte multilayers (PEMs) films containing benzydamine hydrochloride (Benz)-loaded casein nanoparticles are developed aiming to increase the structure drug loading efficiency and to prolong the drug release. The multilayers are built on biodegradable polyester substrates, which are previously charged in a corona discharge. Medium viscosity sodium alginate (SA) is used as a partner in the multilayer formulation. The SA and the casein nanoparticles are deposited on the substrate using the layer-by-layer (LbL) deposition technique. The drug loading efficiency and the release kinetics in artificial saliva are determined spectrophotometrically.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

IEEE Transactions on Dielectrics and Electrical Insulation 工程技术-工程：电子与电气

CiteScore

6.00

自引率

22.60%

发文量

309

审稿时长

5.2 months

期刊介绍： Topics that are concerned with dielectric phenomena and measurements, with development and characterization of gaseous, vacuum, liquid and solid electrical insulating materials and systems; and with utilization of these materials in circuits and systems under condition of use.