低出生体重与牙釉质发育缺陷的关系：系统回顾与荟萃分析

IF 2.1 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-05-27 DOI:10.1016/j.archoralbio.2025.106313

Eugênia Lívia de Andrade Dantas , Basílio Rodrigues Vieira , Bianca Marques Santiago , Yuri Wanderley Cavalcanti , Frederico Barbosa de Sousa

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引用次数: 0

摘要

目的低出生体重（LBW）与发育性牙釉质缺陷（DDE）有关，但尚未对DDE的病因生理学模型（etii - phys模型）进行验证。本研究旨在探讨：(i)乳牙（DEC）和恒牙（PERM）中LBW与DDE以及磨牙-门牙低矿化（MIH）之间的关系，以及（ii）观察到的DDE风险与基于ti-物理模型的预测风险（model-based）之间的关系。截止2024年4月，在PubMed、ISI Web of Science、LILACS、SCOPUS和Embase中检索了横断面、队列和病例对照研究，并辅以灰色文献检索。对DDE/MIH患者的LBW进行随机效应模型meta分析。亚组分析检查了DDE的PRE风险。结果meta分析共纳入60篇文章。观察到的DDE风险与基于模型的DDE风险相关（p <； 0.001,r = 0.64）[永久性DDE(相对风险=1.30；1.02-1.64) <； DEC中的DDE (RR= 1.76；1.52-2.04) <； DDE in DEC+veryLBW (RR = 2.55；2.09-3.10) <； DEC发育不全(RR= 3.30；2.35-4.62) <； DEC+veryLBW发育不全(RR = 4.62；[3.26-6.56]在DEC中，而在PERM中没有（p = 0.49）。关于LBW和MIH的有限数据阻碍了DDE观察风险和基于模型风险之间关联的计算。结论结合DDE的etii - phys模型，有证据表明LBW与乳牙的DDE有因果关系，而与恒牙列没有因果关系。关于LBW和MIH的证据仍然有限。

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Association of low birth weight with development defects of enamel: Systematic review with meta-analysis

Objective

Low birth weight (LBW) has been associated with developmental defects of enamel (DDE), but this has not been tested against an etiological physiological model of DDE (Eti-Phys model). This study aimed to investigate the associations: (i) between LBW and DDE as well as molar-incisor hypomineralization (MIH) in deciduous (DEC) and permanent teeth (PERM), and (ii) between observed and Eti-Phys-model-based predicted (model-based) risk of DDE.

Design

Cross-sectional, cohort, and case-control studies were identified in PubMed, ISI Web of Science, LILACS, SCOPUS, and Embase until April 2024, supplemented by grey literature searches. Random-effects model meta-analyses were performed for LBW in DDE/MIH. Subgroup analyses examined the PRE risk of DDE.

Results

60 articles were included in meta-analyses. Observed and model-based risks of DDE were correlated (p < 0.001, r = 0.64) [DDE in permanent (relative risk =1.30; 1.02–1.64) < DDE in DEC (RR= 1.76; 1.52–2.04) < DDE in DEC+veryLBW (RR = 2.55; 2.09–3.10) < hypoplasia in DEC (RR= 3.30; 2.35–4.62) < hypoplasia in DEC+veryLBW (RR = 4.62; 3.26–6.56)] in DEC, but not in PERM (p = 0.49). Limited data on LBW versus MIH hindered the calculation of an association between observed and model-based risks of DDE.

Conclusion

Combined with the Eti-Phys model of DDE, the evidence suggests a causal association between LBW and DDE in the deciduous, but not in the permanent dentition. Evidence on LBW and MIH remains limited.

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry