RAS/ERK信号和PLK1：协调发育调控和疾病机制

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-06-03 DOI:10.1016/j.ceb.2025.102544

Han Bit Baek , Swathi Arur

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引用次数: 0

摘要

RAS/ERK信号通路是细胞增殖、分化和存活等过程的关键调控因子，是驱动细胞发育的核心机制。RAS/ERK信号的失调与包括RASopathies在内的发育障碍以及各种癌症有关。polo样激酶1 （PLK1）是减数分裂和有丝分裂细胞周期的重要协调者，在细胞发育中起着同样重要的作用。值得注意的是，异常的ERK信号可以产生与PLK1缺乏引起的表型非常相似的表型，这表明这些途径之间存在功能交叉。在这篇综述中，我们探讨了在发育过程中RAS/ERK和PLK1信号传导之间的新联系，并强调了它们相互作用可能控制的广泛的生物过程。

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RAS/ERK signaling and PLK1: Coordinating developmental regulation and disease mechanisms

The RAS/ERK signaling pathway is a critical regulator of cellular processes such as proliferation, differentiation, and survival, core mechanisms that drive development. Dysregulation of RAS/ERK signaling is implicated in developmental disorders, including RASopathies, as well as in various cancers. Polo-like kinase 1 (PLK1) is a crucial orchestrator of both meiotic and mitotic cell cycle and plays an equally important role in development. Notably, abnormal ERK signaling can produce phenotypes that closely resemble those caused by PLK1 deficiency, suggesting a functional intersection between these pathways. In this review, we explore the emerging links between RAS/ERK and PLK1 signaling during development and highlight the broad range of biological processes potentially governed by their interaction.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.