{"title":"传统中药牛膝在民族医学中的多样性生物活性","authors":"Yuvaraj Dinakarkumar , Gnanasekaran Ramakrishnan , Ponmozhi Marimuthu , Santhan Velayudham Priya , Sharmila Kumar , Vaagdevi Mukkavilli","doi":"10.1016/j.prenap.2025.100268","DOIUrl":null,"url":null,"abstract":"<div><div>A popular ethnomedical herb, <em>Achyranthes aspera</em> has a long history in traditional medicine because of its many medicinal uses. Tannins, alkaloids, flavonoids, and saponins are among the many bioactive substances that have been found through phytochemical studies and contribute to its therapeutic qualities. This herb has been thoroughly investigated in contemporary pharmacology, revealing its anti-inflammatory, antimicrobial, and cardiovascular-modulating properties despite having strong roots in traditional treatments. It is important for treating oxidative stress-related conditions like degenerative and chronic inflammatory diseases because of its strong antioxidant activity. According to scientific research, the plant's anti-inflammatory qualities effectively lower inflammation by modifying pro-inflammatory cytokines. It has the potential to treat diseases naturally because of its antibacterial action, which has been shown against a variety of pathogens. Its pharmacological relevance is further expanded by its cardiovascular-modulating activities, which include antihypertensive and cardioprotective properties. Furthermore, <em>Achyranthes aspera</em>'s antioxidant qualities are essential in the fight against oxidative stress, which is connected to a number of chronic illnesses, such as cancer, diabetes, and neurological diseases. This review highlights the plant's potential to aid in the creation of innovative medicinal substances and as sources of novel drug development since it combines traditional medical practices with contemporary pharmacological understanding.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100268"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diverse bioactivity of traditional herb Achyranthes aspera in ethnomedicine\",\"authors\":\"Yuvaraj Dinakarkumar , Gnanasekaran Ramakrishnan , Ponmozhi Marimuthu , Santhan Velayudham Priya , Sharmila Kumar , Vaagdevi Mukkavilli\",\"doi\":\"10.1016/j.prenap.2025.100268\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A popular ethnomedical herb, <em>Achyranthes aspera</em> has a long history in traditional medicine because of its many medicinal uses. Tannins, alkaloids, flavonoids, and saponins are among the many bioactive substances that have been found through phytochemical studies and contribute to its therapeutic qualities. This herb has been thoroughly investigated in contemporary pharmacology, revealing its anti-inflammatory, antimicrobial, and cardiovascular-modulating properties despite having strong roots in traditional treatments. It is important for treating oxidative stress-related conditions like degenerative and chronic inflammatory diseases because of its strong antioxidant activity. According to scientific research, the plant's anti-inflammatory qualities effectively lower inflammation by modifying pro-inflammatory cytokines. It has the potential to treat diseases naturally because of its antibacterial action, which has been shown against a variety of pathogens. Its pharmacological relevance is further expanded by its cardiovascular-modulating activities, which include antihypertensive and cardioprotective properties. Furthermore, <em>Achyranthes aspera</em>'s antioxidant qualities are essential in the fight against oxidative stress, which is connected to a number of chronic illnesses, such as cancer, diabetes, and neurological diseases. This review highlights the plant's potential to aid in the creation of innovative medicinal substances and as sources of novel drug development since it combines traditional medical practices with contemporary pharmacological understanding.</div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"7 \",\"pages\":\"Article 100268\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199725001284\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199725001284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Diverse bioactivity of traditional herb Achyranthes aspera in ethnomedicine
A popular ethnomedical herb, Achyranthes aspera has a long history in traditional medicine because of its many medicinal uses. Tannins, alkaloids, flavonoids, and saponins are among the many bioactive substances that have been found through phytochemical studies and contribute to its therapeutic qualities. This herb has been thoroughly investigated in contemporary pharmacology, revealing its anti-inflammatory, antimicrobial, and cardiovascular-modulating properties despite having strong roots in traditional treatments. It is important for treating oxidative stress-related conditions like degenerative and chronic inflammatory diseases because of its strong antioxidant activity. According to scientific research, the plant's anti-inflammatory qualities effectively lower inflammation by modifying pro-inflammatory cytokines. It has the potential to treat diseases naturally because of its antibacterial action, which has been shown against a variety of pathogens. Its pharmacological relevance is further expanded by its cardiovascular-modulating activities, which include antihypertensive and cardioprotective properties. Furthermore, Achyranthes aspera's antioxidant qualities are essential in the fight against oxidative stress, which is connected to a number of chronic illnesses, such as cancer, diabetes, and neurological diseases. This review highlights the plant's potential to aid in the creation of innovative medicinal substances and as sources of novel drug development since it combines traditional medical practices with contemporary pharmacological understanding.