马凡氏综合征患者行走时髋关节总关节力矩发生改变

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-05-31 DOI:10.1016/j.clinbiomech.2025.106570

Amara G. Sharp , Mariana V. Jacobs , Anthony A. Mangino , Jody L. Clasey , Mary B. Sheppard , Michael A. Samaan

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引用次数: 0

摘要

马凡氏综合征是一种遗传性结缔组织疾病，与肌肉骨骼无力、韧带松弛和下肢关节疼痛相关。大约46%的马凡综合征患者报告髋关节相关疼痛，但马凡综合征患者步态时髋关节瞬间发生的潜在改变尚不清楚。本研究的目的是评估马凡氏综合征患者与健康对照者行走时的髋关节总关节力矩。方法对18例马凡氏综合征患者和18例性别和BMI相匹配的无症状对照组进行固定步行速度下的地面三维步态分析。总关节力矩计算为整个站立阶段平面内矢状面、正面面和横向面髋部力矩平方和的平方根。使用协方差分析评估组间髋关节总关节峰值力矩的差异以及站立前半段和后半段髋关节总关节峰值力矩的平面贡献。结果：与对照组相比，马凡组在站立前半段髋关节总力矩的第一个峰值更大（p = 0.01），矢状面贡献百分比更大（p = 0.03），额面力矩更大（p = 0.02），额面贡献（p = 0.02）。在第一个和第二个关节总力矩峰值处较高的内展力矩可以作为步态干预的生物力学目标，以减少可能与马方人群髋关节相关疼痛相关的髋关节负荷。

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Alterations of the hip total joint moment occur during walking in individuals with Marfan syndrome

Background

Marfan Syndrome is an inherited connective tissue disorder associated with musculoskeletal weakness, ligamentous laxity, and lower extremity joint pain. Approximately 46 % of individuals with Marfan Syndrome report hip-related pain yet the underlying alterations that occur in hip joint moments during gait in the Marfan population is not well understood. The purpose of this study was to assess the hip total joint moment during walking in individuals with Marfan Syndrome compared to healthy controls.

Methods

Overground 3D gait analysis at a fixed walking speed was conducted for eighteen individuals with Marfan Syndrome and eighteen sex and BMI matched, asymptomatic controls. The total joint moment was calculated as the square root of the sum of the squared planar internal sagittal, frontal, and transverse plane hip moments across the stance phase. Between group differences in peak hip total joint moment and the planar contributions to the peak hip total joint moments during the first and second halves of stance were assessed using an analysis of covariance.

Findings

Compared to the control group, the Marfan group walked with greater first peak total hip joint moments (p = 0.01), greater sagittal plane percent contribution (p = 0.03), and greater frontal plane moments (p = 0.02), and frontal plane contributions (p = 0.02) to the hip total joint moment in the first and second half of stance.

Interpretation

Higher internal abduction moments at the first and second peak total joint moment may serve as a biomechanical target for gait interventions to reduce hip joint loading that may be associated with hip-related pain in the Marfan population.

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.