脂基纳米载体在皮肤感染的局部应用

IF 4.2 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2025-05-16 DOI:10.1016/j.coph.2025.102541

Monali M. Upare , Koustubh Mansing Thorawade , Abhay Prakash Mishra , Manisha Nigam , Neti Waranuch

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引用次数: 0

摘要

皮肤感染是一个重要的医疗问题，特别是随着抗生素耐药性的上升。脂质体、sln和NLCs等lbn有望在治疗皮肤感染时增强局部药物输送。它们改善了抗菌剂的溶解度、稳定性和持续释放，允许更深的皮肤渗透。它们的生物相容性和包封各种药物的能力使它们对细菌和真菌感染有效。然而，诸如稳定性问题（聚集、融合、沉淀和氧化）、监管障碍（缺乏具体指南）和制造可扩展性等挑战限制了它们的临床应用。本文综述了脂基纳米载体通过局部递送治疗皮肤感染的益处、进展和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lipid-based nanocarriers in topical applications for skin infections

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Lipid-based nanocarriers in topical applications for skin infections

Skin infections are a significant healthcare issue, particularly with rising AMR. LBNs like liposomes, SLNs, and NLCs hold promise for enhancing topical drug delivery in treating skin infections. They improve solubility, stability, and sustained release of antimicrobial agents, allowing deeper skin penetration. Their biocompatibility and ability to encapsulate various drugs make them effective against bacterial and fungal infections. However, challenges such as stability issues (aggregation, fusion, sedimentation, and oxidation), regulatory hurdles (lack of specific guidelines), and manufacturing scalability limit their clinical use. This article reviews the benefits, advancements, and challenges of lipid-based nanocarriers for treating skin infections through topical delivery.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.