降压治疗对脂蛋白的影响仅仅是“副作用”吗?哌唑嗪与美托洛尔的比较。

Acta medica Scandinavica Pub Date : 1988-01-01
H Lithell, K Haglund, F Granath, J Ostman
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引用次数: 0

摘要

37名仰卧收缩压大于160和/或舒张压大于95 mmHg的患者参加了这项研究,并接受了6个月的吡唑嗪和6个月的美托洛尔治疗(随机顺序)。两种治疗后收缩压和舒张压均无差异(中位差0/0 mmHg)。然而,血清胆固醇的平均值和中位数差异分别为0.4和0.3 mmol/l,分别为预处理值的9%和5%。相应的动脉粥样硬化指数(高密度脂蛋白中胆固醇的综合指数)的差异为预处理值的10%和8%。在相同血压水平下,两种药物代谢反应的差异很可能对缺血性心脏病的长期预防很重要,而高水平的血清胆固醇和动脉粥样硬化指数是缺血性心脏病的主要危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Are effects of antihypertensive treatment on lipoproteins merely "side-effects"? A comparison of prazosin and metoprolol.

Thirty-seven patients with a supine systolic blood pressure greater than 160 and/or a diastolic blood pressure greater than 95 mmHg were enrolled in the study and treated for 6 months with prazosin and 6 months with metoprolol (in random order). Neither the systolic nor the diastolic blood pressures differed after the two types of treatment (median difference 0/0 mmHg). The mean and median differences in serum cholesterol, however, were 0.4 and 0.3 mmol/l respectively, which were 9 and 5% of the pretreatment values. The corresponding differences in the atherogenic index (in which cholesterol in high density lipoproteins is integrated) were 10 and 8% of the pretreatment values. This difference in the metabolic response to the two drugs at the same blood pressure level is most probably of importance in the long-term prevention of ischaemic heart disease, for which high levels of serum cholesterol and atherogenic index are major risk factors.

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