碳水化合物来源的纳米抗氧化剂减轻心肌缺血再灌注损伤

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-29 DOI:10.1016/j.colsurfb.2025.114832

Wenpei Fu , Cheng Deng , Zhen Wang , Mengrong He , Ying Bai , Jia Xu , Shiying Li , Qiaofeng Jin , Li Zhang , Mingxing Xie , Yali Yang

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引用次数: 0

摘要

心肌缺血再灌注损伤（MIRI）是影响再灌注治疗缺血性心肌病疗效和心脏移植术后预后的关键因素。活性氧（ROS）的过量产生是MIRI病理进展的重要因素。减少ROS的产生可以有效缓解MIRI。在最近的研究中，纳米抗氧化剂显示出良好的活性氧清除作用，在活性氧相关疾病中显示出良好的治疗效果。然而，这些纳米抗氧化剂的临床应用往往受到复杂的制备工艺和降解挑战的阻碍。在本研究中，我们合成了一种名为碳水化合物衍生纳米颗粒（C-NPs）的纳米抗氧化剂，并验证了其清除ROS的能力。用C-NPs预处理MIRI模型大鼠可显著降低受损心肌组织中的ROS水平，提示在缓解MIRI方面具有潜在的治疗益处。此外，在心脏移植过程中，C-NPs被用于治疗供体心脏，以进一步研究它们是否能减轻心脏移植的IRI。结果表明，C-NPs在一定程度上减轻了移植物的炎症反应，延长了同种异体移植物的存活时间，显示出减少心脏移植后急性排斥反应的潜力。

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Carbohydrate-derived nano-antioxidant for attenuating myocardial ischemia-reperfusion injury

Myocardial ischemia‒reperfusion injury (MIRI) is a critical factor that impacts the efficacy of reperfusion therapy in treating ischemic cardiomyopathy and the posttransplant outcomes of heart transplant patients. Excessive production of reactive oxygen species (ROS) is a significant contributor to the pathological progress of MIRI. Reducing ROS production can effectively alleviate MIRI. Nanoantioxidants have shown good ROS scavenging effects in recent studies, demonstrating promising therapeutic outcomes in ROS-related diseases. However, the clinical application of these nanoantioxidants is often hindered by complex preparation processes and degradation challenges. In this study, we synthesized a nanoantioxidant named carbohydrate-derived nanoparticles (C-NPs) and verified its ability to scavenge ROS. Pretreatment of MIRI model rats with C-NPs significantly reduced ROS levels in damaged myocardial tissue, suggesting a potential therapeutic benefit in alleviating MIRI. Furthermore, C-NPs were used to treat donor hearts during heart transplantation to further investigate whether they could attenuate IRI in cardiac grafts. The results indicated that C-NPs alleviated graft inflammation to some extent and prolonged the survival of allografts, showing the potential to reduce acute rejection after heart transplantation.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.