芳香族苯甲酸类似物胡椒碱共晶的机械合成及其理化性质研究

IF 3.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Crystal Growth & Design Pub Date : 2025-05-25 DOI:10.1021/acs.cgd.5c0052010.1021/acs.cgd.5c00520

Mohsin Khan, Diptajyoti Gogoi, Bishal Pal Hazarika, Mihails Arhangelskis, Silpi S. Borah, Khaled Althubeiti, Shrinivas Purandare and Ranjit Thakuria*,

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引用次数: 0

摘要

胡椒碱（PIPE）是一种天然生物碱，具有几种GRAS共晶，即4HBA， 26DHBA和PABA，可形成新的共晶。利用PXRD和单晶XRD进一步对合成的共晶进行了表征。根据我们的研究，我们发现PIPE•PABA一水共晶是所有合成的共晶中最稳定的形式，并且在潮湿环境下不会发生共晶解离和/或相变。另一方面，浆液搅拌表明PIPE•4HBA共晶可能发生相变，而PIPE•26DHBA共晶可能发生解离。PIPE中缺乏氢键给基可能是PIPE共晶报道有限的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanosynthesis of Piperine Cocrystals with an Aromatic Benzoic Acid Analogue and Their Physicochemical Property Study

Cocrystallization of piperine (PIPE), a natural alkaloid with several GRAS coformers, namely, 4HBA, 26DHBA, and PABA, resulted in the formation of new cocrystals. All of the synthesized cocrystals were further characterized using PXRD and single-crystal XRD analysis. Based on our investigation, it was observed that PIPE•PABA monohydrate cocrystal is the most stable form among all the synthesized cocrystals and does not undergo cocrystal dissociation and/or phase transformation under a humid environment. On the other hand, slurry stirring shows possible phase transformation of the PIPE•4HBA cocrystal and dissociation in the case of the PIPE•26DHBA cocrystal. The absence of a hydrogen bond donor group in PIPE might be the reason behind limited reports on PIPE cocrystals.

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来源期刊

Crystal Growth & Design 化学-材料科学：综合

CiteScore

6.30

自引率

10.50%

发文量

650

审稿时长

1.9 months

期刊介绍： The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials. Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.