膜受体的聚类:来自DNA折纸方法的见解

IF 13 2区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Small Pub Date : 2025-06-03 DOI:10.1002/smll.202503543
Carmen M. Domínguez, Christof M. Niemeyer
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引用次数: 0

摘要

细胞信号传导使细胞能够解释和响应其环境,依赖于调节关键生物功能的受体相互作用。虽然受体-配体亲和力至关重要,但受体聚类在调节信号传导效率方面起着核心作用,受膜扩散性、脂质组织和受体-受体相互作用等因素的影响。虽然成像技术的进步长期以来有助于更好地理解这一基本的生物学机制,但最近纳米技术的突破,特别是DNA折纸纳米结构(DONs)的使用,现在使精确操纵受体-配体相互作用成为可能。这开启了对纳米尺度信号转导动力学的前所未有的见解,并具有创新治疗应用的潜力。本文中介绍的基于不同类型受体的例子说明了这些突破性的发展如何不仅可以导致更详细的机制理解,而且还为开发新的分子疗法铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clustering of Membrane Receptors: Insights from DNA Origami-Based Approaches

Clustering of Membrane Receptors: Insights from DNA Origami-Based Approaches
Cell signaling enables cells to interpret and respond to their environment, relying on receptor interactions that regulate key biological functions. While receptor-ligand affinity is crucial, receptor clustering plays a central role in modulating signaling efficiency, influenced by factors such as membrane diffusivity, lipid organization, and receptor-receptor interactions. While advances in imaging have long contributed to a better understanding of this fundamental biological mechanism, recent breakthroughs in nanotechnology, particularly the use of DNA origami nanostructures (DONs), now enable the precise manipulation of receptor-ligand interactions. This opens up unprecedented insights into the dynamics of signal transduction at the nanoscale and holds promising potential for innovative therapeutic applications. The examples presented in this article, based on various classes of receptors, illustrate how these groundbreaking developments can not only lead to a more detailed mechanistic understanding, but also pave the way for the development of new molecular therapies.
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来源期刊
Small
Small 工程技术-材料科学:综合
CiteScore
17.70
自引率
3.80%
发文量
1830
审稿时长
2.1 months
期刊介绍: Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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