{"title":"跨越卢比孔河:脑干过氧化氢水平驱动睡眠-觉醒动力学","authors":"Nicole M. Gilette, Jonathan O. Lipton","doi":"10.1016/j.cmet.2025.05.005","DOIUrl":null,"url":null,"abstract":"A crucial goal of sleep science is to uncover the molecular mechanisms that translate sleep need into neural pathways that discharge sleep/wake transitions. In a new study, Tian et al.<span><span><sup>1</sup></span></span> provide support in living animals that peroxide in the substantia nigra is a critical driver of these states.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"168 1","pages":""},"PeriodicalIF":27.7000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CROSsing the Rubicon: Brainstem peroxide levels drive sleep-wake dynamics\",\"authors\":\"Nicole M. Gilette, Jonathan O. Lipton\",\"doi\":\"10.1016/j.cmet.2025.05.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A crucial goal of sleep science is to uncover the molecular mechanisms that translate sleep need into neural pathways that discharge sleep/wake transitions. In a new study, Tian et al.<span><span><sup>1</sup></span></span> provide support in living animals that peroxide in the substantia nigra is a critical driver of these states.\",\"PeriodicalId\":9840,\"journal\":{\"name\":\"Cell metabolism\",\"volume\":\"168 1\",\"pages\":\"\"},\"PeriodicalIF\":27.7000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell metabolism\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cmet.2025.05.005\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell metabolism","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.cmet.2025.05.005","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
CROSsing the Rubicon: Brainstem peroxide levels drive sleep-wake dynamics
A crucial goal of sleep science is to uncover the molecular mechanisms that translate sleep need into neural pathways that discharge sleep/wake transitions. In a new study, Tian et al.1 provide support in living animals that peroxide in the substantia nigra is a critical driver of these states.
期刊介绍:
Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others.
Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.