高血糖通过促进神经元CCL2增加小鼠的焦虑

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Senegal Carty
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引用次数: 0

摘要

糖尿病患者的压力水平会升高。了解血糖异常是否会通过影响神经信号传导而导致这种效果,有助于开发减少糖尿病患者焦虑的治疗方法。发表在《自然-代谢》杂志上的一项新研究报告称,在糖尿病小鼠模型中,神经元中促炎趋化因子CCL2的表达增加导致小鼠在高血糖期间焦虑样行为增加。阻断大脑中的CCL2信号导致高血糖小鼠的这些行为显著减少,这表明这种趋化因子在糖尿病引起的焦虑中起作用。在这些结果的基础上,研究人员假设抑制大脑中的CCL2信号可以减少糖尿病小鼠的焦虑。他们通过脑室内注射给接受链脲佐菌素治疗的小鼠和非糖尿病对照组小鼠注射抗ccl2抗体来验证这一假设,然后进行行为测试以测量焦虑水平。他们的研究结果表明,诱发糖尿病会增加老鼠的焦虑水平。然而,与未抑制CCL2信号传导的糖尿病小鼠相比,接受脑室内抗CCL2的糖尿病小鼠表现出更少的焦虑样行为,这支持了抑制CCL2信号传导减轻小鼠糖尿病诱导的焦虑的假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Hyperglycaemia increases anxiety in mice by boosting neuronal CCL2

Hyperglycaemia increases anxiety in mice by boosting neuronal CCL2
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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