具有协同抗氧化和压电效应的ce掺杂生物活性玻璃/BaTiO₃复合陶瓷增强骨修复

IF 6.3 2区材料科学 Q2 CHEMISTRY, PHYSICAL

Journal of Alloys and Compounds Pub Date : 2025-06-02 DOI:10.1016/j.jallcom.2025.181357

Junqin Mao , Heng Zheng , Qiuyu Zeng , Yutong Zhang , Guoyu Lv

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引用次数: 0

摘要

在这项研究中，开发了一种结合掺铈生物活性玻璃（CeBG）和钛酸钡（BaTiO₃）的复合陶瓷材料，利用抗氧化性能和压电响应性的协同效应，从而增强了承重骨缺损的修复。采用高温烧结法制备了CeBG掺杂浓度（5%和15%）不同的CeBG- batio₃复合材料。采用压电常数（d33）、x射线衍射（XRD）、扫描电镜（SEM）、热重分析（TGA）和维氏硬度对陶瓷进行了表征。体外模拟过氧化氢酶活性、细胞相容性、血液相容性、DPPH自由基清除能力等实验对生物相容性和抗氧化能力进行了测定。d33为1.6 pC/N的15% CeBG-BaTiO₃陶瓷具有较好的致密性、结晶度和力学性能。CeBG- batio3陶瓷具有良好的生物性能，CeBG含量越高，抗氧化性能越好。

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Ce-doped bioactive glass/BaTiO₃ composite ceramics with synergistic antioxidative and piezoelectric effects for enhanced bone repair

In this study, a composite ceramic material combining cerium-doped bioactive glass (CeBG) and barium titanate (BaTiO₃) was developed to harness the synergistic effects of antioxidant properties and piezoelectric responsiveness, thereby enhancing the repair of load-bearing bone defects. CeBG-BaTiO₃ composites with varying CeBG doping concentrations (5 % and 15 %) were fabricated via high-temperature sintering. The ceramics were studied by piezoelectric constants (d₃₃), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and Vichers hardness. In vitro simulation of catalase activity, cytocompatibility, hemocompatibility assay and DPPH radical scavenging assay were selected for biocompatibility and antioxidant capacity. 15 % CeBG-BaTiO₃ ceramic with d₃₃ of 1.6 pC/N has better densification, crystallinity and mechanical property. CeBG-BaTiO₃ ceramics have favorable biological performance and exhibit increased antioxidant properties with more CeBG.

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来源期刊

Journal of Alloys and Compounds 工程技术-材料科学：综合

CiteScore

11.10

自引率

14.50%

发文量

5146

审稿时长

67 days

期刊介绍： The Journal of Alloys and Compounds is intended to serve as an international medium for the publication of work on solid materials comprising compounds as well as alloys. Its great strength lies in the diversity of discipline which it encompasses, drawing together results from materials science, solid-state chemistry and physics.