探讨标准、低亮度视力及Moorfields视力表作为遗传性视网膜疾病的预后指标。

IF 2.4
Laura J Taylor, Amandeep S Josan, Robert E MacLaren
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引用次数: 0

摘要

标准视力(VA)通常对遗传性视网膜疾病引起的视力的细微变化不敏感。低亮度VA (LLVA)作为一种替代的视敏度测量方法越来越受欢迎。一种新的测试,Moorfields视力表(MAC)被设计为一种更敏感和可重复的测试,用于年龄相关性黄斑变性患者。该研究探讨了标准VA、LLVA和MAC在遗传性视网膜疾病患者混合队列中的实用性和可重复性。方法:招募参与者作为视网膜变性视觉功能研究的一部分(伦理参考文献20/WM/0283)。标准VA采用早期治疗糖尿病视网膜病变研究(ETDRS)图表放置在4米。使用相同的ETDRS图,添加2.0 log单位中性密度滤波器,获得LLVA。使用标准诊室照明获得MAC VA。所有参与者都完成了重复测试。结果:35名患者和36名健康对照者完成了测试,logMAR为1.00(6/60)或更高。与患者参与者和健康对照组的标准VA相比,LLVA和MAC VA都降低了(线性混合模型:p)。结论:所有三种视力测试都可以被认为是临床试验的可行结果指标。对于早期至中度遗传性视网膜疾病(logMAR 1.00(6/60)或更好)的患者,没有单一的视力检查显示出明显的益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring standard and low luminance visual acuity and the Moorfields Acuity Chart as outcome measures in inherited retinal disease.

Introduction: Standard visual acuity (VA) is often insensitive to subtle changes in vision that result from inherited retinal disease. Low luminance VA (LLVA) has grown in popularity as an alternative acuity measure. A new test, the Moorfields Acuity Chart (MAC) has been designed as a more sensitive and repeatable test for use in patients with age-related macular degeneration. The study explores the utility and repeatability of standard VA, LLVA and the MAC in a mixed cohort of patients with inherited retinal disease.

Methods: Participants were recruited as part of the visual function in retinal degeneration study (Ethics Reference 20/WM/0283). Standard VA was obtained using the Early Treatment of Diabetic Retinopathy study (ETDRS) chart placed at 4 m. LLVA was obtained using the same ETDRS chart with the addition of a 2.0-log unit neutral density filter. MAC VA was obtained using standard clinic room lighting. All participants completed repeated testing.

Results: Thirty-five patient participants and 36 healthy controls, with logMAR 1.00 (6/60) or better, completed testing. Both LLVA and MAC VA were reduced compared to standard VA in patient participants and healthy controls (linear mixed model: p < 0.001). All three acuity tests show comparable sensitivity, specificity and repeatability. A subset of participants (patient participants n = 34, healthy controls n = 35) completed microperimetry. Post hoc analysis of microperimetry volume sensitivity correlated significantly with all of the acuity tests and showed no significant difference in the gradient of the slopes. This suggests that VA, LLVA and MAC VA decline at a consistent rate with disease progression.

Conclusion: All three acuity tests could be considered viable outcome measures for clinical trials. For patients with early to moderate inherited retinal disease (logMAR 1.00 (6/60) or better), no single acuity chart appeared significantly beneficial.

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