Ashi Robert Thobias, Mrugdha Patel, Chirag Vaghela, Prabhudas Shankarbhai Patel
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Oncogenic human papillomavirus (HPV) has been strongly implicated in the etiology of cervical cancer and its prevalence in patients with head and neck cancers, particularly oropharyngeal cancers (OPCs), is increasing at an alarming rate. In developed Western nations, HPV is responsible for approximately 90% of all OPC cases, while the proportion of HPV-related OPCs is progressively rising in developing countries. The 8th edition of the American Joint Committee on Cancer (AJCC) now incorporates HPV status as part of the staging system for oropharyngeal cancers. Moreover, due to distinct molecular pathways, the clinical presentation of HPV-positive tumors differs from that of HPV-negative tumors, a phenomenon supported by numerous studies. Despite these differences, the treatment regimens for HPV-associated cancers generally remain analogous to those for their HPV-negative counterparts. This review aims to elucidate the unique tumor characteristics and underlying molecular aberrations associated with HPV-induced malignancies.
期刊介绍：
Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.
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