成纤维细胞活化蛋白（FAP）：转移性黑色素瘤微环境的关键调节剂。

IF 0.4 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI:10.4103/ijnm.ijnm_79_24

Ghasemali Divband, Raheleh Hedayati, Hamidreza Amini, Leila Hassanzadeh

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引用次数: 0

摘要

一位55岁男性晚期恶性黑色素瘤患者接受了手术、放疗和化疗。尽管进行了这些治疗，[18F]FDG PET/CT显示疾病进展明显。使用镓-68示踪剂对CXCR4、SSTR2和FAP进行靶向成像，确定了个性化治疗的生物标志物。这导致了[177Lu]Lu-FAPI-2286的选择。在第一个周期后，患者报告疼痛缓解，但随后的影像学显示快速脑转移。这个病例强调了个性化医疗和分子成像在治疗晚期黑色素瘤中的重要性。

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Fibroblast Activation Protein (FAP): A Crucial Modulator of the Microenvironment in Metastatic Melanoma Case.

A 55-year-old male with advanced malignant melanoma received surgery, radiotherapy, and chemotherapy. Despite these treatments, [18F]FDG PET/CT showed significant disease progression. Targeted imaging with gallium-68 radiotracers for CXCR4, SSTR₂, and FAP identified biomarkers for personalized therapy. This led to the choice of [177Lu]Lu-FAPI-2286. After the first cycle, the patient reported pain relief, but subsequent imaging revealed rapid brain metastasis. This case highlights the importance of personalized medicine and molecular imaging in treating advanced melanoma.

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来源期刊

Indian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.70

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0.00%

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