{"title":"含异香草素咪唑骨架荧光探针检测细胞肺通气保护状态下亚硫酸盐。","authors":"Weifeng Yan, Shengyang Deng, Xiaoyun Guo, Rui Li","doi":"10.1007/s10895-025-04389-6","DOIUrl":null,"url":null,"abstract":"<p><p>Herein, a fluorescent probe named IsoIm-SF with the isovanillin-containing imidazo backbone was developed for detecting sulfite in cellular pulmonary ventilation protection condition. In solution, the established pulmonary ventilation protection condition suggested no obvious impact on the detection. IsoIm-SF exhibited high sensitivity, long linear range, high steadiness, rapid response, high selectivity, and low cytotoxicity. In pulmonary cells, IsoIm-SF realized the imaging of both the exogenous and endogenous sulfite. Further, IsoIm-SF might monitor the sulfite level to indicate the pulmonary ventilation protection efficacy, including that contributed by the anesthetic treatment. This work was a challenging trial for establishing the anesthetic-related therapeutics to improve the methodology of the pulmonary ventilation protection.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Fluorescent Probe with Isovanillin-Containing Imidazole Backbone for Detecting Sulfite in Cellular Pulmonary Ventilation Protection Condition.\",\"authors\":\"Weifeng Yan, Shengyang Deng, Xiaoyun Guo, Rui Li\",\"doi\":\"10.1007/s10895-025-04389-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Herein, a fluorescent probe named IsoIm-SF with the isovanillin-containing imidazo backbone was developed for detecting sulfite in cellular pulmonary ventilation protection condition. In solution, the established pulmonary ventilation protection condition suggested no obvious impact on the detection. IsoIm-SF exhibited high sensitivity, long linear range, high steadiness, rapid response, high selectivity, and low cytotoxicity. In pulmonary cells, IsoIm-SF realized the imaging of both the exogenous and endogenous sulfite. Further, IsoIm-SF might monitor the sulfite level to indicate the pulmonary ventilation protection efficacy, including that contributed by the anesthetic treatment. This work was a challenging trial for establishing the anesthetic-related therapeutics to improve the methodology of the pulmonary ventilation protection.</p>\",\"PeriodicalId\":15800,\"journal\":{\"name\":\"Journal of Fluorescence\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Fluorescence\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s10895-025-04389-6\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10895-025-04389-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
A Fluorescent Probe with Isovanillin-Containing Imidazole Backbone for Detecting Sulfite in Cellular Pulmonary Ventilation Protection Condition.
Herein, a fluorescent probe named IsoIm-SF with the isovanillin-containing imidazo backbone was developed for detecting sulfite in cellular pulmonary ventilation protection condition. In solution, the established pulmonary ventilation protection condition suggested no obvious impact on the detection. IsoIm-SF exhibited high sensitivity, long linear range, high steadiness, rapid response, high selectivity, and low cytotoxicity. In pulmonary cells, IsoIm-SF realized the imaging of both the exogenous and endogenous sulfite. Further, IsoIm-SF might monitor the sulfite level to indicate the pulmonary ventilation protection efficacy, including that contributed by the anesthetic treatment. This work was a challenging trial for establishing the anesthetic-related therapeutics to improve the methodology of the pulmonary ventilation protection.
期刊介绍：
Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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