青少年和青年癌症幸存者在开始抗肥胖药物治疗后的体重相关结局

IF 1.2 4区医学 Q4 ONCOLOGY

Journal of adolescent and young adult oncology Pub Date : 2025-06-02 DOI:10.1089/jayao.2025.0031

Amy M Berkman, Clark R Andersen, Stephanie B Dixon, Amanda Ramirez, Katherine Gilmore, Whittney Thoman, Zayd A Razouki, David Santos, Sonali Thosani, J A Livingston, Michelle A T Hildebrandt, Michael E Roth

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引用次数: 0

摘要

抗肥胖药物（AOMs）尚未在青少年和年轻成人（AYA）癌症幸存者中进行研究。在这项回顾性分析中，惩罚样条的广义加性混合模型描述了AYA癌症幸存者的身体质量指数（BMI）随时间的变化。总结aom前最大和最后一次随访时的体重和BMI，置信区间为95%。在中位随访249天期间，63.4%的幸存者体重减轻≥5%。严重肥胖的幸存者比例从60%下降到35%。这些发现表明，AOMs对AYA癌症幸存者的体重减轻有效。

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Weight-Related Outcomes Among Survivors of Adolescent and Young Adult Cancer after Anti-Obesity Medication Initiation.

Anti-obesity medications (AOMs) have not been studied in survivors of adolescent and young adult (AYA) cancer. In this retrospective analysis, generalized additive mixed model with penalized spline described body mass index (BMI) over time among survivors of AYA cancer prescribed an AOM. Body weight and BMI at pre-AOM maximum and last follow-up were summarized, with 95% confidence intervals. Over a median follow-up time of 249 days, 63.4% of survivors had ≥5% weight reduction. The proportion of survivors with severe obesity decreased from 60% to 35%. These findings suggest that AOMs are effective for weight reduction in survivors of AYA cancer.

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来源期刊

Journal of adolescent and young adult oncology ONCOLOGY-

CiteScore

3.70

自引率

15.00%

发文量

114

期刊介绍： Journal of Adolescent and Young Adult Oncology (JAYAO) breaks new ground as the first cancer journal dedicated to all aspects of adolescent and young adult (AYA)-aged cancer patients and survivors. JAYAO is the only central forum for peer-reviewed articles, reviews, and research in the field, bringing together all AYA oncology stakeholders and professionals across disciplines, including clinicians, researchers, psychosocial and supportive care providers, and pediatric and adult cancer institutions.