两周补铁对5岁以下儿童铁状态的影响：一项前瞻性队列研究。

IF 1.7 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-06-02 DOI:10.1007/s13312-025-00099-1

Krishna Nesara, Dhandapany Gunasekaran, Sharbari Basu

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引用次数: 0

摘要

目的：评价预防性双周补充铁和叶酸（IFA）（National Iron Plus Initiative）在维持5岁以下儿童铁充足状态中的效果。方法：连续筛查铁状态正常（血红蛋白和血清铁蛋白正常）的健康儿童开始铁预防治疗，每两周服用1 mL含20 mg元素铁和100 μ g叶酸的糖浆，为期6个月。比较补充前后血红蛋白和血清铁蛋白水平。结果：在573名接受筛查的儿童中，没有人常规接受IFA预防。在200名符合条件的儿童中，共有173名完成了干预，6个月时平均血红蛋白（SD） [11.7 (0.5)-11.9 (0.5) g/dL]和血清铁蛋白[54.5 (23.5)- 63.6 (21.1)μ g/L]显著增加(P结论：每两周补充铁和叶酸可改善1至5岁铁充足儿童的铁状态。

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Efficacy of Biweekly Iron Supplementation on Iron Status in Under-Five Children: A Prospective Cohort Study.

Objective: To evaluate the efficacy of prophylactic biweekly Iron and Folic acid (IFA) supplementation (National Iron Plus Initiative) in maintaining iron status in under-five children with iron sufficiency.

Methods: Consecutive healthy children screened for normal iron status (normal hemoglobin and serum ferritin) were started on iron prophylaxis as one mL syrup containing 20 mg elemental iron and 100 µg folic acid biweekly for six months. The pre- and post-supplementation hemoglobin and serum ferritin levels were compared.

Results: Out of 573 children screened, none were receiving IFA prophylaxis routinely. A total of 173 out of 200 eligible children completed the intervention with a significant increase in the mean (SD) hemoglobin [11.7 (0.5)-11.9 (0.5) g/dL] and serum ferritin [54.5 (23.5)- 63.6 (21.1) µg/L] at six months (P < 0.001).

Conclusions: Biweekly iron and folic acid supplementation improved iron status in children aged 1 to 5 years with iron sufficiency.

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.