Paula Sirera-Sirera, Núria Lluís, Fèlix Lluís, Pedro Zapater, Pablo López-Guillén, José M Ramia-Ángel, Rahma Amrani, Trinidad Castillo-García, José Andreu-Viseras, Karina Cárdenas-Jaén, Lucía Guilabert, Sara Pérez-Brotons, Emma Martínez-Moneo, Nerea Gendive-Martin, Iván González Hermoso, Enrique de-Madaria, María José Ferri
{"title":"粪便弹性酶-1和13c -混合甘油三酯呼气试验与脂肪吸收系数诊断胰腺手术后外分泌胰功能不全的比较","authors":"Paula Sirera-Sirera, Núria Lluís, Fèlix Lluís, Pedro Zapater, Pablo López-Guillén, José M Ramia-Ángel, Rahma Amrani, Trinidad Castillo-García, José Andreu-Viseras, Karina Cárdenas-Jaén, Lucía Guilabert, Sara Pérez-Brotons, Emma Martínez-Moneo, Nerea Gendive-Martin, Iván González Hermoso, Enrique de-Madaria, María José Ferri","doi":"10.1016/j.gastrohep.2025.502492","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Exocrine pancreatic insufficiency (EPI) is common after pancreatic surgery. In patients with chronic pancreatitis, our previous results supported the use of fecal elastase-1 (FE-1) over the <sup>13</sup>C-mixed triglyceride breath test (<sup>13</sup>C-MTBT) for the diagnosis of EPI. However, it is poorly established how the performance of these two tests compares to the diagnosis of EPI after pancreatic surgery.</p><p><strong>Patients and methods: </strong>FE-1 and <sup>13</sup>C-MTBT were compared with the gold standard coefficient of fat absorption (CFA). Area under ROC curve (AUC) and best cutoffs were used to assess presence of EPI. Patient characteristics were evaluated by extent of pancreatic resection.</p><p><strong>Results: </strong>The AUC (95% confidence interval) was 0.724 (0.578-0.871) for FE-1 and 0.640 (0.482-0.799) for <sup>13</sup>C-MTBT in the diagnosis of EPI. A pairwise comparison of the FE-1 and <sup>13</sup>C-MTBT AUCs showed no statistically significant difference (P=.20). The best cut-off point was 65.5μg/g for FE-1 and 22.5% for <sup>13</sup>C-MTBT. According to contingency analysis, both the FE-1 threshold of 65.5μg/g (P=.005) and the <sup>13</sup>C-MTBT threshold of 22.5% (P=.015) showed statistical significance for diagnosing EPI.</p><p><strong>Conclusion: </strong>FE-1 was more accurate for diagnosing EPI after pancreatic surgery, but the differences were not statistically different.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502492"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fecal elastase-1 and <sup>13</sup>C-mixed triglyceride breath test vs. coefficient of fat absorption to diagnose exocrine pancreatic insufficiency after pancreatic surgery.\",\"authors\":\"Paula Sirera-Sirera, Núria Lluís, Fèlix Lluís, Pedro Zapater, Pablo López-Guillén, José M Ramia-Ángel, Rahma Amrani, Trinidad Castillo-García, José Andreu-Viseras, Karina Cárdenas-Jaén, Lucía Guilabert, Sara Pérez-Brotons, Emma Martínez-Moneo, Nerea Gendive-Martin, Iván González Hermoso, Enrique de-Madaria, María José Ferri\",\"doi\":\"10.1016/j.gastrohep.2025.502492\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Exocrine pancreatic insufficiency (EPI) is common after pancreatic surgery. In patients with chronic pancreatitis, our previous results supported the use of fecal elastase-1 (FE-1) over the <sup>13</sup>C-mixed triglyceride breath test (<sup>13</sup>C-MTBT) for the diagnosis of EPI. However, it is poorly established how the performance of these two tests compares to the diagnosis of EPI after pancreatic surgery.</p><p><strong>Patients and methods: </strong>FE-1 and <sup>13</sup>C-MTBT were compared with the gold standard coefficient of fat absorption (CFA). Area under ROC curve (AUC) and best cutoffs were used to assess presence of EPI. Patient characteristics were evaluated by extent of pancreatic resection.</p><p><strong>Results: </strong>The AUC (95% confidence interval) was 0.724 (0.578-0.871) for FE-1 and 0.640 (0.482-0.799) for <sup>13</sup>C-MTBT in the diagnosis of EPI. A pairwise comparison of the FE-1 and <sup>13</sup>C-MTBT AUCs showed no statistically significant difference (P=.20). The best cut-off point was 65.5μg/g for FE-1 and 22.5% for <sup>13</sup>C-MTBT. According to contingency analysis, both the FE-1 threshold of 65.5μg/g (P=.005) and the <sup>13</sup>C-MTBT threshold of 22.5% (P=.015) showed statistical significance for diagnosing EPI.</p><p><strong>Conclusion: </strong>FE-1 was more accurate for diagnosing EPI after pancreatic surgery, but the differences were not statistically different.</p>\",\"PeriodicalId\":12802,\"journal\":{\"name\":\"Gastroenterologia y hepatologia\",\"volume\":\" \",\"pages\":\"502492\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastroenterologia y hepatologia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.gastrohep.2025.502492\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterologia y hepatologia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.gastrohep.2025.502492","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Fecal elastase-1 and 13C-mixed triglyceride breath test vs. coefficient of fat absorption to diagnose exocrine pancreatic insufficiency after pancreatic surgery.
Objective: Exocrine pancreatic insufficiency (EPI) is common after pancreatic surgery. In patients with chronic pancreatitis, our previous results supported the use of fecal elastase-1 (FE-1) over the 13C-mixed triglyceride breath test (13C-MTBT) for the diagnosis of EPI. However, it is poorly established how the performance of these two tests compares to the diagnosis of EPI after pancreatic surgery.
Patients and methods: FE-1 and 13C-MTBT were compared with the gold standard coefficient of fat absorption (CFA). Area under ROC curve (AUC) and best cutoffs were used to assess presence of EPI. Patient characteristics were evaluated by extent of pancreatic resection.
Results: The AUC (95% confidence interval) was 0.724 (0.578-0.871) for FE-1 and 0.640 (0.482-0.799) for 13C-MTBT in the diagnosis of EPI. A pairwise comparison of the FE-1 and 13C-MTBT AUCs showed no statistically significant difference (P=.20). The best cut-off point was 65.5μg/g for FE-1 and 22.5% for 13C-MTBT. According to contingency analysis, both the FE-1 threshold of 65.5μg/g (P=.005) and the 13C-MTBT threshold of 22.5% (P=.015) showed statistical significance for diagnosing EPI.
Conclusion: FE-1 was more accurate for diagnosing EPI after pancreatic surgery, but the differences were not statistically different.
期刊介绍：
Gastroenterology and Hepatology is the first journal to cover the latest advances in pathology of the gastrointestinal tract, liver, pancreas, and bile ducts, making it an indispensable tool for gastroenterologists, hepatologists, internists and general practitioners.
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