{"title":"局部应用凝血酶溶液在扁桃体切除术中的益处：一项双盲研究。","authors":"Raadhika Shree, Meenakshi Srinivasan","doi":"10.1111/coa.14330","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>This study aims to evaluate the benefit of topical haemocoagulase application during tonsillectomy in diminishing the operation time and intraoperative blood loss, as well as postoperative healing effects.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A randomised controlled trial was conducted including 60 patients undergoing tonsillectomy with or without adenoidectomy. The patients were randomly assigned into two groups of 30 each: the topical haemocoagulase applied in the tonsillectomy procedure as Group A (<i>n</i> = 30) (interventional group) and patients undergoing tonsillectomy using a conventional saline pressure pack as Group B (<i>n</i> = 30) (control group). After obtaining informed and written consent from the study population, patients were categorised into Group A and Group B through randomisation. Outcome measures evaluated included operation time, intraoperative blood loss, slough formation and clearance rate, postoperative pain and feeding habits. Data analysis was performed using SPSS version 19, employing descriptive statistics, Shapiro–Wilk tests for normality, independent <i>t</i>-tests for normally distributed data and chi-square tests for categorical variables, with statistical significance set at <i>p</i> < 0.05.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Results revealed that Group A had significantly reduced operation times (<i>p</i> < 0.001), less intraoperative blood loss, faster slough clearance, and improved postoperative feeding habits compared to Group B.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The Topical haemocoagulase is a safe, effective and cost-efficient adjunct in tonsillectomy, offering significant advantages in surgical efficiency and postoperative recovery. Its ease of application and affordability make it a practical addition to routine surgical practice, benefiting both patients and healthcare providers. This study underscores the potential of haemocoagulase to enhance surgical outcomes and improve the overall quality of care in tonsillectomy procedures.</p>\n </section>\n </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 5","pages":"890-896"},"PeriodicalIF":1.5000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Benefit of Topical Haemocoagulase Solution Application in Tonsillectomy: A Double-Blinded Study\",\"authors\":\"Raadhika Shree, Meenakshi Srinivasan\",\"doi\":\"10.1111/coa.14330\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>This study aims to evaluate the benefit of topical haemocoagulase application during tonsillectomy in diminishing the operation time and intraoperative blood loss, as well as postoperative healing effects.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A randomised controlled trial was conducted including 60 patients undergoing tonsillectomy with or without adenoidectomy. The patients were randomly assigned into two groups of 30 each: the topical haemocoagulase applied in the tonsillectomy procedure as Group A (<i>n</i> = 30) (interventional group) and patients undergoing tonsillectomy using a conventional saline pressure pack as Group B (<i>n</i> = 30) (control group). After obtaining informed and written consent from the study population, patients were categorised into Group A and Group B through randomisation. Outcome measures evaluated included operation time, intraoperative blood loss, slough formation and clearance rate, postoperative pain and feeding habits. Data analysis was performed using SPSS version 19, employing descriptive statistics, Shapiro–Wilk tests for normality, independent <i>t</i>-tests for normally distributed data and chi-square tests for categorical variables, with statistical significance set at <i>p</i> < 0.05.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Results revealed that Group A had significantly reduced operation times (<i>p</i> < 0.001), less intraoperative blood loss, faster slough clearance, and improved postoperative feeding habits compared to Group B.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The Topical haemocoagulase is a safe, effective and cost-efficient adjunct in tonsillectomy, offering significant advantages in surgical efficiency and postoperative recovery. Its ease of application and affordability make it a practical addition to routine surgical practice, benefiting both patients and healthcare providers. This study underscores the potential of haemocoagulase to enhance surgical outcomes and improve the overall quality of care in tonsillectomy procedures.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10431,\"journal\":{\"name\":\"Clinical Otolaryngology\",\"volume\":\"50 5\",\"pages\":\"890-896\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Otolaryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/coa.14330\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/coa.14330","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Benefit of Topical Haemocoagulase Solution Application in Tonsillectomy: A Double-Blinded Study
Aim
This study aims to evaluate the benefit of topical haemocoagulase application during tonsillectomy in diminishing the operation time and intraoperative blood loss, as well as postoperative healing effects.
Methods
A randomised controlled trial was conducted including 60 patients undergoing tonsillectomy with or without adenoidectomy. The patients were randomly assigned into two groups of 30 each: the topical haemocoagulase applied in the tonsillectomy procedure as Group A (n = 30) (interventional group) and patients undergoing tonsillectomy using a conventional saline pressure pack as Group B (n = 30) (control group). After obtaining informed and written consent from the study population, patients were categorised into Group A and Group B through randomisation. Outcome measures evaluated included operation time, intraoperative blood loss, slough formation and clearance rate, postoperative pain and feeding habits. Data analysis was performed using SPSS version 19, employing descriptive statistics, Shapiro–Wilk tests for normality, independent t-tests for normally distributed data and chi-square tests for categorical variables, with statistical significance set at p < 0.05.
Results
Results revealed that Group A had significantly reduced operation times (p < 0.001), less intraoperative blood loss, faster slough clearance, and improved postoperative feeding habits compared to Group B.
Conclusion
The Topical haemocoagulase is a safe, effective and cost-efficient adjunct in tonsillectomy, offering significant advantages in surgical efficiency and postoperative recovery. Its ease of application and affordability make it a practical addition to routine surgical practice, benefiting both patients and healthcare providers. This study underscores the potential of haemocoagulase to enhance surgical outcomes and improve the overall quality of care in tonsillectomy procedures.
期刊介绍：
Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with:
current otorhinolaryngological practice
audiology, otology, balance, rhinology, larynx, voice and paediatric ORL
head and neck oncology
head and neck plastic and reconstructive surgery
continuing medical education and ORL training
The emphasis is on high quality new work in the clinical field and on fresh, original research.
Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject.
• Negative/null results
In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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