尿素衍生物自组装成超分子凝胶。

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI:10.1248/cpb.c25-00084

Masamichi Yamanaka, Shinya Kimura

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引用次数: 0

摘要

在这篇综述中，我们介绍了低分子量尿素凝胶（LMWGs）的发展。发现c3对称的三尿素框架是LMWG的优良结构。通过调整分子结构，可以制造出可以在多种介质中凝胶化的低分子分子蛋白，从有机溶剂到水。将适当的官能团引入小分子微分子蛋白中可以反映出所得到的超分子凝胶的功能。我们研制的超分子凝胶作为电泳底物，实现了蛋白质和DNA的分离。考虑到材料的应用，我们还开发了结构简化的单尿素衍生物作为lmwg。

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Self-assembly of Urea Derivatives into Supramolecular Gels.

In this review, we present our development of low-molecular-weight gelators (LMWGs) with urea moieties. A C₃-symmetric tris-urea framework was found to be an excellent structure for LMWG. Tuning the molecular structure has enabled the creation of LMWGs that gel in a wide range of media, ranging from organic solvents to water. The introduction of appropriate functional groups into LMWGs can be reflected in a function of the resulting supramolecular gel. Our developed supramolecular gels were applied as substrates for electrophoresis, and the separation of proteins and DNA was achieved. Considering material applications, we also developed structurally simplified mono-urea derivatives as LMWGs.

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.