Nanami Hirano, Ryoma Tanaka, Dr. Ryu Ukawa-Sato, Dr. Ryuta X. Suzuki, Dr. Joerg Freitag, Hiroshi Hori, Masafumi Kono, Prof. Chihiro Fushimi
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Production of Bio-Gamma-Butyrolactone from Succinic Acid in Bio-Derivable Tetrahydrofuran Solvent
Gamma-butyrolactone (GBL) production from biomass-derived succinic acid (SA) has been actively conducted in recent years. However, petroleum-derived 1,4-dioxane, along with water and ethanol, has been used as the solvent. In this study, we employed bio-derivable tetrahydrofuran (THF), a greener solvent that suppresses GBL overreaction. SA hydrogenation was conducted under milder conditions than in previous studies, with reaction times (1–8 h), temperatures (170–230 °C), and initial H2 pressures (2–4 MPa) varied systematically. Results show that at 230 °C, both GBL consumption and SA side reactions are substantially facilitated. H2 pressure strongly influences GBL selectivity with optimum conditions (initial H2 pressure of 4 MPa, reaction temperature of 200 °C, and reaction time of 6 h), yielding the highest GBL yield (46.8 mol%) and selectivity (55.7 mol%). THF achieved comparable GBL yields and selectivities in the SA–GBL reaction to those of dioxane. In addition, we predict pathways for byproduct formation in the SA–GBL reaction in THF solvent.
期刊介绍：
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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