雾化器压降对人呼吸道呼吸廓形及气溶胶沉积的影响

IF 2.9 3区环境科学与生态学 Q2 ENGINEERING, CHEMICAL

Journal of Aerosol Science Pub Date : 2025-05-25 DOI:10.1016/j.jaerosci.2025.106620

Ondrej Mišík , František Prinz , Jakub Elcner , Matouš Cabalka , Miloslav Bělka , František Lízal

{"title":"雾化器压降对人呼吸道呼吸廓形及气溶胶沉积的影响","authors":"Ondrej Mišík , František Prinz , Jakub Elcner , Matouš Cabalka , Miloslav Bělka , František Lízal","doi":"10.1016/j.jaerosci.2025.106620","DOIUrl":null,"url":null,"abstract":"<div><div>Breathing flow rate profiles are crucial for predicting aerosol drug delivery. While aerosol particle characteristics are determined by the inhalation device, breathing profiles are patient-specific, making them an essential topic for personalized medicine.</div><div>This study investigates the influence of nebulizer pressure drop on breathing profiles and subsequent aerosol deposition within human airways. Ten male subjects performed spontaneous, and slow and deep breathing manoeuvres through three different nebulizers (one jet and two mesh nebulizers). Breathing profiles were recorded, and the impact of nebulizer pressure drop on flow rate profiles was analyzed. Computational modelling of airway aerosol deposition was performed for particles ranging from 1 to 10 μm in diameter, based on the recorded boundary conditions.</div><div>The jet nebulizer exhibited the most significant flow rate decrease due to its high pressure drop, increasing particle deposition in the lower airways. These findings are important for personalized modelling and the application of a digital twin approach in treatment design, leading to more effective and targeted drug delivery.</div></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"188 ","pages":"Article 106620"},"PeriodicalIF":2.9000,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airways\",\"authors\":\"Ondrej Mišík , František Prinz , Jakub Elcner , Matouš Cabalka , Miloslav Bělka , František Lízal\",\"doi\":\"10.1016/j.jaerosci.2025.106620\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Breathing flow rate profiles are crucial for predicting aerosol drug delivery. While aerosol particle characteristics are determined by the inhalation device, breathing profiles are patient-specific, making them an essential topic for personalized medicine.</div><div>This study investigates the influence of nebulizer pressure drop on breathing profiles and subsequent aerosol deposition within human airways. Ten male subjects performed spontaneous, and slow and deep breathing manoeuvres through three different nebulizers (one jet and two mesh nebulizers). Breathing profiles were recorded, and the impact of nebulizer pressure drop on flow rate profiles was analyzed. Computational modelling of airway aerosol deposition was performed for particles ranging from 1 to 10 μm in diameter, based on the recorded boundary conditions.</div><div>The jet nebulizer exhibited the most significant flow rate decrease due to its high pressure drop, increasing particle deposition in the lower airways. These findings are important for personalized modelling and the application of a digital twin approach in treatment design, leading to more effective and targeted drug delivery.</div></div>\",\"PeriodicalId\":14880,\"journal\":{\"name\":\"Journal of Aerosol Science\",\"volume\":\"188 \",\"pages\":\"Article 106620\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-05-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Aerosol Science\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0021850225000977\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Aerosol Science","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021850225000977","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}

引用次数: 0

摘要

呼吸流速曲线是预测气溶胶给药的关键。虽然气溶胶颗粒的特征是由吸入装置决定的，但呼吸特征是针对患者的，这使得它们成为个性化医疗的基本主题。本研究探讨了喷雾器压降对呼吸廓形和随后的气溶胶在人气道内沉积的影响。10名男性受试者通过三个不同的雾化器（一个喷射雾化器和两个网状雾化器）进行自发的、缓慢的深呼吸。记录了呼吸曲线，分析了雾化器压降对流量曲线的影响。基于记录的边界条件，对直径为1 ~ 10 μm的颗粒进行了气道气溶胶沉积的计算模拟。射流喷雾器由于其高压降，增加了下气道的颗粒沉积，导致流量下降最为显著。这些发现对于个性化建模和数字孪生方法在治疗设计中的应用非常重要，从而导致更有效和更有针对性的药物输送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Influence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airways

Breathing flow rate profiles are crucial for predicting aerosol drug delivery. While aerosol particle characteristics are determined by the inhalation device, breathing profiles are patient-specific, making them an essential topic for personalized medicine.

This study investigates the influence of nebulizer pressure drop on breathing profiles and subsequent aerosol deposition within human airways. Ten male subjects performed spontaneous, and slow and deep breathing manoeuvres through three different nebulizers (one jet and two mesh nebulizers). Breathing profiles were recorded, and the impact of nebulizer pressure drop on flow rate profiles was analyzed. Computational modelling of airway aerosol deposition was performed for particles ranging from 1 to 10 μm in diameter, based on the recorded boundary conditions.

The jet nebulizer exhibited the most significant flow rate decrease due to its high pressure drop, increasing particle deposition in the lower airways. These findings are important for personalized modelling and the application of a digital twin approach in treatment design, leading to more effective and targeted drug delivery.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Aerosol Science 环境科学-工程：化工

CiteScore

8.80

自引率

8.90%

发文量

127

审稿时长

35 days

期刊介绍： Founded in 1970, the Journal of Aerosol Science considers itself the prime vehicle for the publication of original work as well as reviews related to fundamental and applied aerosol research, as well as aerosol instrumentation. Its content is directed at scientists working in engineering disciplines, as well as physics, chemistry, and environmental sciences. The editors welcome submissions of papers describing recent experimental, numerical, and theoretical research related to the following topics: 1. Fundamental Aerosol Science. 2. Applied Aerosol Science. 3. Instrumentation & Measurement Methods.