COVID-19从母亲到新生儿的垂直传播：204项研究的系统回顾和荟萃分析

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-05-13 DOI:10.1016/j.jiph.2025.102825

Fatemeh Movahed , Fariba Haji Hosseini , Afshin Heidari , Masoud Dehbozorgi , Mina Ataei , Farnaz Vahidi , Romina Abyaneh , Bahar Bajelan , Mahmood Bakhtiyari , Arman Shafiee

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引用次数: 0

摘要

本研究估计了SARS-CoV-2垂直传播的流行率，并确定了母婴传播的危险因素。截至2024年5月，对PubMed、Scopus和Web of Science的全面搜索发现，在28,543条记录中，有204项观察性研究，其中包括通过RT-PCR确认检测到SARS-CoV-2的新生儿。总体垂直传播率为4 %(95 % CI: 4 % -5 %)，异质性显著（I²= 75 %）。传播因分娩方式、收入分类和地区而异，低收入地区和剖宫产的传播较高。母体母乳中检测到SARS-CoV-2罕见。新生儿sars - cov -2特异性IgG抗体较多，IgM抗体较少。研究结果强调了垂直传播的罕见性，但强调了医疗保健实践中的差异。进一步的高质量研究，特别是在低收入地区的研究，对于更深入地了解不同临床环境中的垂直传播动态至关重要。

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COVID-19 vertical transmission from mothers to neonates: A systematic review and meta-analysis of 204 studies

This study estimates the prevalence of vertical transmission of SARS-CoV-2 and identifies risk factors for mother-to-neonate transmission. A comprehensive search of PubMed, Scopus, and Web of Science up to May 2024 identified 204 observational studies, out of 28,543 records, that included neonates with confirmed SARS-CoV-2 detection via RT-PCR. The overall vertical transmission rate was 4 % (95 % CI: 4 %–5 %), with notable heterogeneity (I² = 75 %). Transmission varied based on delivery method, income classification, and region, being higher in lower-income areas and cesarean deliveries. Maternal SARS-CoV-2 detection in breast milk was rare. Neonatal SARS-CoV-2-specific IgG antibodies were frequently detected, while IgM antibodies were less common. The findings highlight the infrequency of vertical transmission but underline disparities in healthcare practices. Further high-quality studies, especially in low-income regions, are essential for a deeper understanding of vertical transmission dynamics in diverse clinical settings.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.