数字通信信息对日本母亲HPV疫苗决策的影响：一项随机对照试验

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-06-03 DOI:10.1016/j.vaccine.2025.127327

Kana Kobayashi , Ken Masuda , Joseph T. Wu , Leesa Lin

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引用次数: 0

摘要

背景：在日本，人乳头瘤病毒（HPV）疫苗的接种受到公众不信任和错误信息的阻碍。了解哪些信息组成部分可以有效地影响母亲的疫苗决策，对于恢复信心和提高覆盖率至关重要。目的：评估不同信息成分对母亲给女儿接种HPV疫苗意愿的影响。方法：本研究采用在线2 × 2 × 2的人间因子随机对照试验，纳入1439名11-18岁女儿的日本母亲的全国代表性样本。参与者被随机分配观看16条基于数字文本的信息中的一条，这些信息有四个组成部分：信使（个人或组织）、内容（有效性或安全性）、风格（讲故事或科学数据）和错误信息（错误信息或事实信息）。结果是接种疫苗的意愿、对疫苗安全性和有效性的信心、信息信任以及对hpv相关疾病的关注。采用Logistic回归和模型拟合统计来评估各成分的影响。结果：在分析的1324名母亲中，与错误信息相比，带有事实信息的信息显著增加了女儿接种疫苗的意愿(25.9%比11.3%；或= 2.75；95% CI = 2.02-3.74)，而对组织信息的信任更高(91.6%；or = 1.58；95% ci = 1.10-2.27)。讲故事信息比科学数据更能增加人们对hpv相关疾病的关注(40.4% vs. 31.9%, OR = 1.45；95% ci = 1.15-1.82)。尽管事实信息和可信来源对态度产生积极影响，但单一的数字信息不足以显著提高疫苗接种率。此外，错误信息降低了人们对疫苗安全性和有效性的信心。结论：在日本，由组织提供的包含事实信息的数字信息对母亲为女儿接种HPV疫苗的意图产生了积极影响。这些发现支持强调可信来源和事实内容的战略，同时打击错误信息，以提高疫苗的信心和吸收。该研究已在Clinicaltrials.gov注册（NCT06347627）。

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Impact of digital communication message on HPV vaccine decision-making among Japanese mothers: A randomized controlled trial

Background: In Japan, human papillomavirus (HPV) vaccine uptake has been hindered by public distrust and misinformation. Understanding which message components can effectively influence mothers' vaccine decision-making is critical for restoring confidence and improving coverage.

Objective: To assess the impact of different message components on mothers' willingness to vaccinate their daughters against HPV.

Methods: This study employed an online 2 × 2 × 2 × 2 between-person factorial randomized controlled trial with a nationally representative sample of 1439 Japanese mothers of daughters aged 11–18. Participants were randomly assigned to view one of 16 digital text-based messages varying by four components: messenger (individual or organization), content (effectiveness or safety), style (storytelling or scientific data), and misinformation (misinformation or factual information). Outcomes were willingness to vaccinate, confidence in vaccine safety and effectiveness, message trust, and concern about HPV-related diseases. Logistic regression and model fit statistics were used to assess the impact of components.

Results: Among 1324 mothers analyzed, messages with factual information significantly increased willingness to vaccinate daughters compared to misinformation (25.9 % vs. 11.3 %; OR = 2.75; 95 % CI = 2.02–3.74), while trust was higher for organizational messages (91.6 %; OR = 1.58; 95 % CI = 1.10–2.27). Storytelling messages increased concerns about HPV-related diseases more than scientific data (40.4 % vs. 31.9 %, OR = 1.45; 95 % CI = 1.15–1.82). Although factual information and trusted sources positively influenced attitudes, a single digital message was insufficient to significantly increase vaccination uptake. Furthermore, misinformation reduced confidence in vaccine safety and effectiveness.

Conclusions: Digital messages containing factual information and delivered by organizations positively influence mothers' intentions to vaccinate their daughters against HPV in Japan. These findings support strategies that emphasize trusted sources and factual content while countering misinformation to improve vaccine confidence and uptake. The study was registered at Clinicaltrials.gov (NCT06347627).

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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