体内微重力加剧牙周炎。

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontal research Pub Date : 2025-05-31 DOI:10.1111/jre.70000

Ahmed Bakri, Asmaa Ismail, Alaa Mansour, Xavier Struillou, Iman M Talaat, Adel B Elmoselhi, Zahi Badran

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引用次数: 0

摘要

这是第一个在体内模拟微重力条件下观察诱发性牙周炎的研究。微重力显著增加了牙槽骨丢失，GCF碱性磷酸酶水平升高，并引起严重的牙周破坏，伴有明显的免疫细胞浸润。了解潜在的分子途径可以指导未来在太空和地球上治疗牙周炎。

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Microgravity Exacerbates Periodontitis In Vivo.

This is the first study to examine induced periodontitis under simulated microgravity in vivo. Microgravity significantly increased alveolar bone loss, elevated GCF alkaline phosphatase levels, and caused severe periodontal destruction with notable immune cell infiltration. Understanding the underlying molecular pathways may guide future treatments for periodontitis in space and on Earth.

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来源期刊

Journal of periodontal research 医学-牙科与口腔外科

CiteScore

6.90

自引率

5.70%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.