rs7041多态性与伊朗多囊卵巢综合征妇女不孕和复发性妊娠丢失的关系

IF 1.6 Q2 MULTIDISCIPLINARY SCIENCES

BMC Research Notes Pub Date : 2025-05-31 DOI:10.1186/s13104-025-07312-1

Hediyeh Hamidi, Asma Kheirollahi, Akram Vatannejad

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引用次数: 0

摘要

目的：探讨rs7041基因多态性与PCOS、不孕症及复发性妊娠丢失（RPL）的关系。结果：基因型分析显示，GT基因型和rs7041多态性的T等位基因与PCOS的发病率增加相关。(或:2.8 95%可信区间(1.48 - -5.33),p = 0.002,或:2.27 - 95% CI [1.2 - -4.28], p = 0.01)。此外，GT基因型和rs7041多态性的T等位基因与PCOS女性不孕的几率增加有关。(OR: 40.55 95% CI [5.34-307.7], p

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The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.

Objective: This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients.

Results: Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48-5.33], p = 0.002, and OR: 2.27 95% CI [1.2-4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34-307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele.

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来源期刊

BMC Research Notes Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

3.60

自引率

0.00%

发文量

363

审稿时长

15 weeks

期刊介绍： BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.