使用草药产品治疗儿童气痛:一项基于问卷的研究和生物碱含量分析。

IF 3.3 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Semih Bulut, Nazmi Mutlu Karakaş, Ayhan İbrahim Aysal, Didem Deliorman Orhan
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引用次数: 0

摘要

背景:草药产品已用于儿童气痛多年。然而,用于儿童的草药产品的质量和产品中是否存在污染是有争议的。本研究旨在评估小儿气痛患者使用中草药产品的频率、家长对使用中草药产品的态度以及用于气痛的中草药产品的吡咯利西啶生物碱含量。方法:研究的调查部分于2020年6月15日- 2020年9月15日在Gazi大学附属医院儿科门诊进行。调查是与家长面对面进行的。使用SPSS 23软件对数据进行分析。在研究的另一部分,从香料商店、市场和网站购买了28种常用的用于治疗气痛的草药产品,并通过LC-QTOF-MS分析评估了它们的吡咯利西啶生物碱含量。结果:31.5%的参与者让他们的孩子使用草药产品治疗气痛。当检查用于儿童气痛的植物时,茴香以51.3%的使用率排名第一。大多数参与者(59%)从香料商店购买了用于腹痛的植物。在75%的用于气痛的草药产品中检测到浓度超过10µg/kg的吡咯利西啶生物碱。结论:在社会各阶层,给儿童使用草药产品治疗气痛。家长们大多从香料店购买草药产品。由于所含的吡咯利西啶类生物碱,如果长期高剂量食用,出售的治疗胃痛的产品可能会对儿童造成肝毒性。用于气痛的草药产品应在医生/药剂师的咨询下使用,并应从药房获得。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of herbal products for gas pain in children: a questionnaire-based study and alkaloid content analysis.

Background: Herbal products have been used for gas pains in children for many years. However, the quality of herbal products used in children and the presence of contamination in the products are controversial. This study was conducted to evaluate the frequency of use of herbal products for gas pain in pediatric patients, the attitudes of parents towards the use of herbal products, and the pyrrolizidine alkaloid content of herbal products used for gas pain.

Methods: The survey part of the study was conducted between 15.06.2020-15.09.2020 at Gazi University Hospital Pediatrics Clinics. The surveys were conducted face to face with the parents. The Statistical Package for Social Sciences (SPSS) 23 program was used in the analysis of the data. In the other part of the study, 28 herbal products frequently used in gas pain were purchased from spice shops, markets and internet sites and their pyrrolizidine alkaloid content was evaluated by LC-QTOF-MS analysis.

Results: 31.5% of the participants had their children use herbal products for gas pains. When the plants used for gas pains in children were examined, fennel came first with a usage rate of 51.3%. The plants used in gas pains were purchased from spice shops by most of the participants (59%). The presence of pyrrolizidine alkaloids above 10 µg/kg concentration was detected in 75% of herbal products used in gas pains.

Conclusion: In all segments of society, children are given herbal products for gas pains. Parents mostly buy herbal products from spice shops. Products sold for gas pains may cause hepatotoxic effects in children when consumed for a long time and in high doses due to the pyrrolizidine alkaloids they contain. Herbal products to be used in gas pain should be used under the consultancy of a physician/pharmacist and should be obtained from pharmacies.

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来源期刊
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
6.10
自引率
2.60%
发文量
300
审稿时长
19 weeks
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