Sema Öznur Çeltik, Arif Önder, Berhan Akdağ, Sadıka Halide Akbaş, Berke Öztürk, Mehmet Emre Gül, Mehmet Fatih Bütün, Hilal Yazıcı Kopuz, Özge Gizli Çoban, Aslı Sürer Adanır
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Serum Levels of Nitric Oxide, SIRT1, MMP-9 and Telomerase in Children With Cognitive Disengagement Syndrome
This study aimed to evaluate serum levels of matrix metalloproteinase-9 (MMP-9), telomerase, sirtuin-1 (SIRT1) and nitric oxide (NO) in children diagnosed with cognitive disengagement syndrome (CDS). The sample included 22 children with ‘pure’ CDS and 42 healthy controls. Our findings indicated that serum levels of telomerase and SIRT1 were significantly elevated in the CDS group compared to the control group, while levels of MMP-9 and NO were significantly reduced. When adjusting for age and gender, the presence of CDS significantly predicted higher serum telomerase levels and lower serum MMP-9 and NO levels. However, it was not a significant predictor of serum levels of SIRT1. Additionally, the serum levels of telomerase and SIRT1 were positively related to the severity of daydreaming symptoms in the CDS group but not to sluggishness. This investigation is the first to explore serum levels of MMP-9, SIRT1, telomerase and NO in children with CDS. The results suggest that these biomarkers may serve as potential tools for diagnosing and monitoring CDS. Additional research is required to elucidate the relationship of these biomarkers to specific CDS symptoms, such as daydreaming and sluggishness.
期刊介绍：
International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
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