ILC2在肺部疾病中的多样性、位置和功能

IF 7.5 2区 医学 Q1 IMMUNOLOGY
Mukesh Verma, Uryan I. Can, R. Lee Reinhardt
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引用次数: 0

摘要

2型炎症是由典型的2型细胞因子IL-4、IL-5和IL-13的产生驱动的。2型细胞因子促进粘膜组织粘液产生、先天免疫细胞募集和平滑肌收缩。这些2型炎症的特征是上皮损伤后肺和肠中观察到的哭泣和清扫反应的重要贡献者。虽然这些2型细胞因子是由许多先天和适应性免疫细胞产生的,但2组先天淋巴样细胞(ILC2)是这些细胞因子的关键早期产生者,在形成肺部免疫反应中起关键作用。这篇综述总结了ILC2在肺中的作用,特别强调了它们作为肠-肺轴的一部分的起源,它们在循环和组织居住ILC2群体的独特身份方面的异质性,以及这些相对罕见的免疫细胞如何显著影响肺部疾病的进程。我们还探讨了影响ILC2行为的因素,包括激活、迁移和与环境的交流。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ILC2 Diversity, Location, and Function in Pulmonary Disease

ILC2 Diversity, Location, and Function in Pulmonary Disease

Type-2 inflammation is driven by the production of canonical type-2 cytokines IL-4, IL-5, and IL-13. Type-2 cytokines promote mucus production, innate immune cell recruitment, and smooth muscle contractility in mucosal tissues. These hallmarks of type-2 inflammation are important contributors to the weep-and-sweep responses observed in the lung and intestine after epithelial insults. While these type-2 cytokines are generated by a number of innate and adaptive immune cells, group 2 innate lymphoid cells (ILC2) are key early producers of these cytokines and are critical in shaping immune responses in the lung. This review summarizes the role of ILC2 in the lung with specific emphasis on their origins as part of the gut-lung axis, their heterogeneity with respect to unique identities of circulating and tissue resident ILC2 populations, and how these relatively rare immune cells can significantly impact the course of pulmonary disease. We also explore factors that influence ILC2 behavior with respect to activation, migration, and communication with their environment.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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