SC144对痘病毒复制的抑制作用

IF 4.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Antiviral research Pub Date : 2025-05-29 DOI:10.1016/j.antiviral.2025.106204

Anil Pant , Djamal Brahim Belhaouari , Lara Dsouza , Lalita Priyamvada , Ziyue Wang , Santiago Navarro-Forero , Panayampalli S. Satheshkumar , Zhengqiang Wang , Zhilong Yang

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引用次数: 0

摘要

痘病毒对人类和经济上重要的动物的健康构成重大威胁。虽然最具破坏性的传染病之一天花已被根除，但mpox和其他痘病毒疾病的迅速增加要求开发抗病毒药物。在这里，我们发现SC144，一种报道的细胞gp130途径的小分子抑制剂，可以抑制猴痘、牛痘和牛痘病毒在培养细胞中的复制。有趣的是，SC144可能独立于gp130抑制牛痘病毒复制。我们进一步表明，这种抑制痘病毒复制是通过抑制病毒DNA复制来实现的。SC144的EC50在亚微摩尔范围内，CC50超过250 μM，具有强效和选择性，是进一步开发抗痘病毒的有希望的候选药物。

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Suppression of poxvirus replication by SC144

Poxviruses are a significant threat to the health of human and economically important animals. Although smallpox, one of the most devastating infectious diseases, is eradicated, the rapid rise of mpox and other poxviral diseases call for the development of antivirals. Here, we show that SC144, a reported small molecule inhibitor of cellular gp130 pathway, suppresses the replication of monkeypox, cowpox, and vaccinia viruses in cultured cells. Interestingly, SC144 likely suppresses vaccinia virus replication independent of gp130. We further show that this suppression of poxvirus replication is achieved by inhibiting viral DNA replication. With EC₅₀ in sub-micromolar range and CC₅₀ of over 250 μM, SC144 is potent and selective, making it a promising candidate for further development as an antiviral against poxviruses.

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来源期刊

Antiviral research 医学-病毒学

CiteScore

17.10

自引率

3.90%

发文量

157

审稿时长

34 days

期刊介绍： Antiviral Research is a journal that focuses on various aspects of controlling viral infections in both humans and animals. It is a platform for publishing research reports, short communications, review articles, and commentaries. The journal covers a wide range of topics including antiviral drugs, antibodies, and host-response modifiers. These topics encompass their synthesis, in vitro and in vivo testing, as well as mechanisms of action. Additionally, the journal also publishes studies on the development of new or improved vaccines against viral infections in humans. It delves into assessing the safety of drugs and vaccines, tracking the evolution of drug or vaccine-resistant viruses, and developing effective countermeasures. Another area of interest includes the identification and validation of new drug targets. The journal further explores laboratory animal models of viral diseases, investigates the pathogenesis of viral diseases, and examines the mechanisms by which viruses avoid host immune responses.