长期PM2.5暴露与代谢组学特征之间的关系：一项回顾性队列研究

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-06-02 DOI:10.1016/j.ecoenv.2025.118417

Jia Zhang , Lianshuang Zhang , Mingyu Feng , Shijie Fan , Jianyu Wang , Ping Xu , Guanghe Wang , Yuming Guo , Peng Lu

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引用次数: 0

摘要

据报道，长期暴露于细颗粒物（PM2.5）与炎症和氧化应激有关。然而，潜在的代谢机制仍然知之甚少。目的探讨PM2.5长期暴露与血液代谢组学及代谢途径的关系。方法对2019年中国山东省大学生队列（CUC）中的1930名年轻人进行回顾性队列研究。1 km × 1 km PM2.5网格数据来源于中国高空气污染物（CHAP）数据集。采用液相色谱-质谱法（LC-MS）检测血浆样品的代谢组水平。12个月的PM2.5暴露被定义为长期PM2.5暴露。我们采用单因素方差分析（ANOVA）和多元线性回归模型分析PM2.5长期暴露与血浆代谢物之间的关系。对多元线性回归模型进行了年龄、性别、体重指数（BMI）、体力活动、吸烟状况、被动吸烟状况、饮酒状况、室外停留时间、社会经济状况、平均温度、相对湿度和风速等因素的调整。并按性别进行分层分析。结果PM2.5长期暴露与60种代谢物的变化有关，这些代谢物富集于3种代谢途径，包括酪氨酸代谢、精氨酸生物合成和不饱和脂肪酸生物合成。在分层分析中，观察到女性特异性途径是甘氨酸、丝氨酸和苏氨酸代谢，而男性特异性途径是甘油磷脂代谢。结论长期暴露于PM2.5环境中可能通过干扰氨基酸和不饱和脂肪酸代谢引起炎症和氧化应激。我们的研究结果应该整合到预防策略中，包括加强对高风险暴露人群的监测和促进抗炎饮食。

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Associations between long-term PM2.5 exposure and metabolomic signatures: A retrospective cohort study

Background

Long-term exposure to fine particulate matter (PM_2.5) has been reported to be associated with inflammation and oxidative stress. However, the underlying metabolic mechanisms remain poorly understood.

Objective

To identify the blood metabolome and metabolic pathways associated with long-term PM_2.5 exposure.

Methods

We conducted a retrospective cohort study among 1930 young adults from the Chinese Undergraduate Cohort (CUC) in 2019 in Shandong Province, China. The 1 km × 1 km PM_2.5 grid data were collected from China High Air Pollutants (CHAP) dataset. Liquid chromatography-mass spectrometry (LC-MS) was used to test the plasma samples' metabolome levels. The 12 months of PM_2.5 exposure were defined as long-term PM_2.5 exposure. We used one-way Analysis of Variance (ANOVA) and multiple linear regression model to analyze the associations between long-term exposure to PM_2.5 and plasma metabolites. The multiple linear regression model was adjusted for age, sex, body mass index (BMI), physical activity, smoking status, passive smoking status, alcohol consumption status, outdoor dwell time, socioeconomic status, average temperature, relative humidity and wind speed. In addition, stratified analysis was conducted based on sex.

Results

Long-term exposure to PM_2.5 was associated with 60 altered metabolites enriched in 3 metabolic pathways, including tyrosine metabolism, arginine biosynthesis and unsaturated fatty acids biosynthesis. In the stratified analysis, it was observed that female-specific pathways were glycine, serine, and threonine metabolism, whereas male-specific pathways were glycerophospholipid metabolism.

Conclusion

Long-term exposure to PM_2.5 could possibly induce inflammation and oxidative stress through disturbing amino acid and unsaturated fatty acid metabolism. Our findings should be integrated into preventive strategies, including enhanced monitoring of high-risk exposure groups and the promotion of an anti-inflammatory diet.

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.