Notch通路：神经发生过程中细胞命运的守护者

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-06-02 DOI:10.1016/j.ceb.2025.102543

Rene Gonzalez , Danny Reinberg

{"title":"Notch通路：神经发生过程中细胞命运的守护者","authors":"Rene Gonzalez , Danny Reinberg","doi":"10.1016/j.ceb.2025.102543","DOIUrl":null,"url":null,"abstract":"<div><div>The Notch signaling pathway is essential for cell fate decisions and maintaining epigenetic memory during nervous system development. It regulates neural stem cell maintenance, neuronal–glial differentiation, and neural circuit formation. Notch activation, through ligand–receptor interactions, releases the Notch intracellular domain, which modulates gene expression in the nucleus. This context-dependent regulation allows Notch to balance proliferation and differentiation, integrating with other pathways and epigenetic regulators to preserve neural stem cell identity and respond to environmental cues. Notch signaling dysfunction is linked to various neurological disorders, highlighting its critical role in nervous system development and homeostasis. This review explores the multifaceted functions of Notch signaling, emphasizing its impact on cell fate and epigenetic memory in early neurogenesis and the adult brain.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102543"},"PeriodicalIF":4.3000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Notch pathway: A guardian of cell fate during neurogenesis\",\"authors\":\"Rene Gonzalez , Danny Reinberg\",\"doi\":\"10.1016/j.ceb.2025.102543\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The Notch signaling pathway is essential for cell fate decisions and maintaining epigenetic memory during nervous system development. It regulates neural stem cell maintenance, neuronal–glial differentiation, and neural circuit formation. Notch activation, through ligand–receptor interactions, releases the Notch intracellular domain, which modulates gene expression in the nucleus. This context-dependent regulation allows Notch to balance proliferation and differentiation, integrating with other pathways and epigenetic regulators to preserve neural stem cell identity and respond to environmental cues. Notch signaling dysfunction is linked to various neurological disorders, highlighting its critical role in nervous system development and homeostasis. This review explores the multifaceted functions of Notch signaling, emphasizing its impact on cell fate and epigenetic memory in early neurogenesis and the adult brain.</div></div>\",\"PeriodicalId\":50608,\"journal\":{\"name\":\"Current Opinion in Cell Biology\",\"volume\":\"95 \",\"pages\":\"Article 102543\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Cell Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S095506742500081X\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S095506742500081X","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

Notch信号通路在神经系统发育过程中对细胞命运决定和维持表观遗传记忆至关重要。它调节神经干细胞的维持、神经元-胶质细胞分化和神经回路的形成。Notch激活，通过配体与受体的相互作用，释放Notch胞内结构域，从而调节细胞核中的基因表达。这种依赖于环境的调节允许Notch平衡增殖和分化，与其他途径和表观遗传调节因子结合，以保持神经干细胞的身份并对环境线索作出反应。Notch信号功能障碍与多种神经系统疾病有关，突出了其在神经系统发育和体内平衡中的关键作用。这篇综述探讨了Notch信号的多方面功能，强调了它在早期神经发生和成人大脑中对细胞命运和表观遗传记忆的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Notch pathway: A guardian of cell fate during neurogenesis

The Notch signaling pathway is essential for cell fate decisions and maintaining epigenetic memory during nervous system development. It regulates neural stem cell maintenance, neuronal–glial differentiation, and neural circuit formation. Notch activation, through ligand–receptor interactions, releases the Notch intracellular domain, which modulates gene expression in the nucleus. This context-dependent regulation allows Notch to balance proliferation and differentiation, integrating with other pathways and epigenetic regulators to preserve neural stem cell identity and respond to environmental cues. Notch signaling dysfunction is linked to various neurological disorders, highlighting its critical role in nervous system development and homeostasis. This review explores the multifaceted functions of Notch signaling, emphasizing its impact on cell fate and epigenetic memory in early neurogenesis and the adult brain.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.